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10.12659/MSM.892512 http://scihub22266oqcxt.onion/10.12659/MSM.892512 C4548697!4548697 !25659849     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25659849 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Med+Sci+Monit 2015 ; 21 (ä): 419-25 Nephropedia Template TP {{tp|p=25659849 |t=2015. Proteomic profiling of aging in glomeruli of mice by using two-dimensional differential gel electrophoresis |pdf=|usr=}}{{25659849 }} gab.com Text Proteomic profiling of aging in glomeruli of mice by using two-dimensional differential gel electrophoresis JO: Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=25659849 #FOAvip BACKGROUND: Glomerular proteins were analyzed by proteomics to screen proteins participating in maturation of glomeruli before senescence and to find key proteins involved in the aging process. MATERIAL AND METHODS: Glomeruli of C57BL/6 mice at 8 and 20 weeks were separated by kidney perfusion. Proteomic profiles of glomeruli were investigated by using two-dimensional differential gel electrophoresis and MALDI-TOF mass spectrometry. RESULTS: We identified 22 differentially expressed proteins. Among them, 3 proteins were significantly up-regulated and 19 proteins were significantly down-regulated in mature mice. Out of these 22 proteins, 18% take part in protein transport, protein targeting, and proteolysis; 5% in glycolysis; 14% in transcription; 9% in electron transport; 9% were chaperones; and 9% were hydrolases. CONCLUSIONS: Our results provide insights into the glomerular differentially expressed proteins correlated with renal aging. In this study we found that aging altered the expression of ATP synthase subunit beta. Further studies on this protein might help to understand the mechanism of renal aging. Twit Text FOAVip Proteomic profiling of aging in glomeruli of mice by using two-dimensional differential gel electrophoresis ????Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=25659849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25659849 #FOAvip English Wikipedia <ref>{{Cite pmid|25659849 }}</ref> Proteomic profiling of aging in glomeruli of mice by using two-dimensional differential gel electrophoresis #MMPMID25659849 Liu X ; Fan Q ; Yang G ; Wang L Med Sci Monit 2015[Feb]; 21 (ä): 419-25 PMID25659849 show ga BACKGROUND: Glomerular proteins were analyzed by proteomics to screen proteins participating in maturation of glomeruli before senescence and to find key proteins involved in the aging process. MATERIAL AND METHODS: Glomeruli of C57BL/6 mice at 8 and 20 weeks were separated by kidney perfusion. Proteomic profiles of glomeruli were investigated by using two-dimensional differential gel electrophoresis and MALDI-TOF mass spectrometry. RESULTS: We identified 22 differentially expressed proteins. Among them, 3 proteins were significantly up-regulated and 19 proteins were significantly down-regulated in mature mice. Out of these 22 proteins, 18% take part in protein transport, protein targeting, and proteolysis; 5% in glycolysis; 14% in transcription; 9% in electron transport; 9% were chaperones; and 9% were hydrolases. CONCLUSIONS: Our results provide insights into the glomerular differentially expressed proteins correlated with renal aging. In this study we found that aging altered the expression of ATP synthase subunit beta. Further studies on this protein might help to understand the mechanism of renal aging. |Aging/*metabolism [MESH] |Animals [MESH] |Electrophoresis, Gel, Two-Dimensional [MESH] |Gene Expression Regulation, Developmental/*genetics [MESH] |Kidney Glomerulus/*metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mitochondrial Proton-Translocating ATPases/metabolism [MESH] |Proteome/genetics/*metabolism [MESH]Proteomic profiling of aging in glomeruli of mice by using two-dimensi(epmc).pdf DeepDyve Pubget Overpricing