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2015 ; 3
(2
): 134-9
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Hepatitis C Associated B-cell Non-Hodgkin Lymphoma: Clinical Features and the
Role of Antiviral Therapy
#MMPMID26357640
Tasleem S
; Sood GK
J Clin Transl Hepatol
2015[Jun]; 3
(2
): 134-9
PMID26357640
show ga
The link between chronic hepatitis C virus (HCV) infection and a subset of B-cell
non-Hodgkin lymphomas (B-NHL) is strongly supported by epidemiological studies.
Evidence demonstrating complete regression of lymphoma after antiviral treatments
suggests possible chronic antigenic stimulation for the origin of B-NHL and
provides evidence for a virus-mediated lymphomagenesis. B-NHL is a heterogeneous
group of lymphomas with varied clinical presentation and may be indolent or
aggressive. The optimal management of HCV related B-NHL is not clear. Antiviral
treatment may be sufficient for low-grade lymphomas, but chemotherapy is
necessary in patients with high grade lymphomas. Interferon (IFN)-based antiviral
treatment regimens for HCV infection are limited by poor tolerance and suboptimal
antiviral response. Recently approved novel direct acting antiviral (DAA) drugs
are highly effective and safe. This has opened a new era for the treatment of HCV
related B-NHL alone or in conjunction with chemotherapy. Treatment of HCV
associated B-NHL should be performed in an interdisciplinary approach in close
consultation with hematologist and hepatologist. In this review, we summarize
data regarding clinical features and epidemiology of B-NHL and discuss novel
therapeutic approaches, including DAAs, that may prove to be effective in the
treatment of HCV associated lymphomas.