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Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue
Diagnosis, and Treatment Options
#MMPMID26356634
Khoury T
; Rmeileh AA
; Yosha L
; Benson AA
; Daher S
; Mizrahi M
J Clin Transl Hepatol
2015[Jun]; 3
(2
): 99-108
PMID26356634
show ga
Drug-induced liver injury (DILI) is a rare but potentially life threatening
adverse drug reaction. DILI may mimic any morphologic characteristic of acute or
chronic liver disease, and the histopathologic features of DILI may be
indistinguishable from those of other causes of liver injury, such as acute viral
hepatitis. In this review article, we provide an update on causative agents,
clinical features, pathogenesis, diagnosis modalities, and outcomes of DILI. In
addition, we review results of recently reported genetic studies and updates on
pharmacological and invasive treatments.