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SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in
Primary Biliary Cirrhosis
#MMPMID26347895
Saare M
; Hämarik U
; Venta R
; Panarina M
; Zucchelli C
; Pihlap M
; Remm A
; Kisand K
; Toots U
; Möll K
; Salupere R
; Musco G
; Uibo R
; Peterson P
J Immunol Res
2015[]; 2015
(?): 526518
PMID26347895
show ga
The SP100 family members comprise a set of closely related genes on chromosome
2q37.1. The widely expressed SP100 and the leukocyte-specific proteins SP110 and
SP140 have been associated with transcriptional regulation and various human
diseases. Here, we have characterized the SP100 family member SP140L. The genome
sequence analysis showed the formation of SP140L gene through rearrangements of
the two neighboring genes, SP100 and SP140, during the evolution of higher
primates. The SP140L expression is interferon-inducible with high transcript
levels in B cells and other peripheral blood mononuclear cells. Subcellularly,
SP140L colocalizes with SP100 and SP140 in nuclear structures that are devoid of
SP110, PML, or p300 proteins. Similarly to SP100 and SP140 protein, we detected
serum autoantibodies to SP140L in patients with primary biliary cirrhosis using
luciferase immunoprecipitation system and immunoblotting assays. In conclusion,
our results show that SP140L is phylogenetically recent member of SP100 proteins
and acts as an autoantigen in primary biliary cirrhosis patients.
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