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10.7555/JBR.29.20140007

http://scihub22266oqcxt.onion/10.7555/JBR.29.20140007
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C4547377!4547377!26243515
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suck abstract from ncbi

pmid26243515      J+Biomed+Res 2015 ; 29 (4): 285-97
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  • Statistical analysis for genome-wide association study #MMPMID26243515
  • Zeng P; Zhao Y; Qian C; Zhang L; Zhang R; Gou J; Liu J; Liu L; Chen F
  • J Biomed Res 2015[Jul]; 29 (4): 285-97 PMID26243515show ga
  • In the past few years, genome-wide association study (GWAS) has made great successes in identifying genetic susceptibility loci underlying many complex diseases and traits. The findings provide important genetic insights into understanding pathogenesis of diseases. In this paper, we present an overview of widely used approaches and strategies for analysis of GWAS, offered a general consideration to deal with GWAS data. The issues regarding data quality control, population structure, association analysis, multiple comparison and visual presentation of GWAS results are discussed; other advanced topics including the issue of missing heritability, meta-analysis, set-based association analysis, copy number variation analysis and GWAS cohort analysis are also briefly introduced.
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