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COMMENTARY: IL-4 AND IL-13 RECEPTORS AND SIGNALING #MMPMID26187331
McCormick SM; Heller NM
Cytokine 2015[Sep]; 75 (1): 38-50 PMID26187331show ga
Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development, neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and lead to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics.