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10.1155/2015/913565 http://scihub22266oqcxt.onion/10.1155/2015/913565 C4546758!4546758!26346118     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sarcoma 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26346118|t=2015. Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma |pdf=|usr=}}{{26346118}} gab.com Text Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma JO: Sarcoma http://www.kidney.de/pget.php?&tw=1&pmid=26346118 #FOAvip Purpose. To investigate the efficacy and morbidity of limb-sparing surgery with intraoperative radiotherapy (IORT) for patients with locally recurrent extremity soft tissue sarcoma (ESTS). Methods and Materials. Twenty-six consecutively treated patients were identified in a single institution retrospective analysis of patients with locally recurrent ESTS treated with IORT following salvage limb-sparing resection from May 2000 to July 2011. Fifteen (58%) patients received external beam radiotherapy (EBRT) prior to recurrence (median dose 63?Gy), while 11 (42%) patients received EBRT following IORT (median dose 52?Gy). The Kaplan-Meier product limit method was used to estimate disease control and survival and subsets were compared using a log rank statistic, Cox's regression model was used to determine independent predictors of disease outcome, and toxicity was reported according to CTCAE v4.0 guidelines. Results. With a median duration of follow-up from surgery and IORT of 34.9 months (range: 4 to 139?mos.), 10 patients developed a local recurrence with 4 subsequently undergoing amputation. The 5-year estimate for local control (LC) was 58% (95% CI: 36?75%), for amputation-free was 81% (95% CI: 57?93%), for metastasis-free control (MFC) was 56% (95% CI: 31?75%), for disease-free survival (DFS) was 35% (95% CI: 17?54%), and for overall survival (OS) was 50% (95% CI: 24?71%). Prior EBRT did not appear to influence disease control (LC, p = 0.74; MFC, p = 0.66) or survival (DFS, p = 0.16; OS, p = 0.58). Grade 3 or higher acute and late toxicities were reported for 6 (23%) and 8 (31%) patients, respectively. The frequency of both acute and late grade 3 or higher toxicities occurred equally between patients who received EBRT prior to or after IORT. Conclusions. IORT in combination with oncologic resection of recurrent ESTS yields good rates of local control and limb-salvage with acceptable morbidity. Within the limitations of small subsets, these data suggest that prior EBRT does not significantly influence disease control or toxicity. Twit Text FOAVip Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma ????Sarcoma http://www.kidney.de/pget.php?&tw=1&pmid=26346118 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26346118 #FOAvip English Wikipedia <ref>{{Cite pmid|26346118}}</ref> Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma #MMPMID26346118 Tinkle CL; Weinberg V; Braunstein SE; Wustrack R; Horvai A; Jahan T; O'Donnell RJ; Gottschalk AR Sarcoma 2015[]; 2015 (ä): ä PMID26346118show ga Purpose. To investigate the efficacy and morbidity of limb-sparing surgery with intraoperative radiotherapy (IORT) for patients with locally recurrent extremity soft tissue sarcoma (ESTS). Methods and Materials. Twenty-six consecutively treated patients were identified in a single institution retrospective analysis of patients with locally recurrent ESTS treated with IORT following salvage limb-sparing resection from May 2000 to July 2011. Fifteen (58%) patients received external beam radiotherapy (EBRT) prior to recurrence (median dose 63?Gy), while 11 (42%) patients received EBRT following IORT (median dose 52?Gy). The Kaplan-Meier product limit method was used to estimate disease control and survival and subsets were compared using a log rank statistic, Cox's regression model was used to determine independent predictors of disease outcome, and toxicity was reported according to CTCAE v4.0 guidelines. Results. With a median duration of follow-up from surgery and IORT of 34.9 months (range: 4 to 139?mos.), 10 patients developed a local recurrence with 4 subsequently undergoing amputation. The 5-year estimate for local control (LC) was 58% (95% CI: 36?75%), for amputation-free was 81% (95% CI: 57?93%), for metastasis-free control (MFC) was 56% (95% CI: 31?75%), for disease-free survival (DFS) was 35% (95% CI: 17?54%), and for overall survival (OS) was 50% (95% CI: 24?71%). Prior EBRT did not appear to influence disease control (LC, p = 0.74; MFC, p = 0.66) or survival (DFS, p = 0.16; OS, p = 0.58). Grade 3 or higher acute and late toxicities were reported for 6 (23%) and 8 (31%) patients, respectively. The frequency of both acute and late grade 3 or higher toxicities occurred equally between patients who received EBRT prior to or after IORT. Conclusions. IORT in combination with oncologic resection of recurrent ESTS yields good rates of local control and limb-salvage with acceptable morbidity. Within the limitations of small subsets, these data suggest that prior EBRT does not significantly influence disease control or toxicity. äIntraoperative Radiotherapy in the Management of Locally Recurrent Ext(epmc).pdf DeepDyve Pubget Overpricing