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10.1002/hep.27249

http://scihub22266oqcxt.onion/10.1002/hep.27249
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C4545530!4545530!24913395
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suck abstract from ncbi


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pmid24913395      Hepatology 2015 ; 61 (1): 375-81
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  • Prevention of Portal Hypertension: from Variceal Development to Clinical Decompensation #MMPMID24913395
  • Vorobioff JD; Groszmann RJ
  • Hepatology 2015[Jan]; 61 (1): 375-81 PMID24913395show ga
  • Pharmacological treatment of portal hypertension (PH) has been exclusively devoted to gastro-esophageal varices related events at different frameworks including prophylactic, emergency or preventive therapy. The goals of treatment are to avoid the first bleeding episode, stop active bleeding and prevent bleeding recurrence, respectively. The objective of pre-primary prophylaxis (PPP) is to avoid variceal development and therefore, it necessarily deals with cirrhotic patients at earlier stages of the disease. At these earlier stages, nonselective beta blocker (NSBB) have been ineffective in preventing the development of varices and other complications of PH. Therefore, treatment should not rely on NSBB. It is possible, that at these earlier stages, etiological treatment of liver disease itself could prevent the progression of PH.This review will focus mainly on early treatment of PH, because if successful, it may translate into histological-hemodynamic improvements, avoiding not only variceal development but also other PH related complications, such as ascites and porto-systemic encephalopathy (PSE). Moreover, the advent of new therapies may allow not only the prevention of the complications of PH, but also the chance of a substantial degree of regression in the cirrhotic process with the possible prevention of hepatocellular carcinoma (HCC).
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