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10.1016/j.niox.2015.05.003 http://scihub22266oqcxt.onion/10.1016/j.niox.2015.05.003 C4545383!4545383!26028569     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nitric+Oxide 2015 ; 49 (ä): 8-15 Nephropedia Template TP {{tp|p=26028569|t=2015. Compartmentalized nitric oxide signaling in the resistance vasculature |pdf=|usr=}}{{26028569}} gab.com Text Compartmentalized nitric oxide signaling in the resistance vasculature JO: Nitric Oxide http://www.kidney.de/pget.php?&tw=1&pmid=26028569 #FOAvip Nitric oxide (NO) was first described as a bioactive molecule through its ability to stimulate soluble guanylate cyclase, but the revelation that NO was the endothelium derived relaxation factor drove the field to its modern state. The wealth of research conducted over the past 30 years has provided us with a picture of how diverse NO signaling can be within the vascular wall, going beyond simple vasodilation to include such roles as signaling through protein S-nitrosation. This expanded view of NO?s actions requires highly regulated and compartmentalized production. Importantly, resistance arteries house multiple proteins involved in the production and transduction of NO allowing for efficient movement of the molecule to regulate vascular tone and reactivity. In this review, we focus on the many mechanisms regulating NO production and signaling action in the vascular wall, with a focus on the control of endothelial nitric oxide synthase (eNOS), the enzyme responsible for synthesizing most of the NO within these confines. We also explore how cross talk between the endothelium and smooth muscle in the microcirculation can modulate NO signaling, illustrating that this one small molecule has the capability to produce a plethora of responses. Twit Text FOAVip Compartmentalized nitric oxide signaling in the resistance vasculature ????Nitric Oxide http://www.kidney.de/pget.php?&tw=1&pmid=26028569 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26028569 #FOAvip English Wikipedia <ref>{{Cite pmid|26028569}}</ref> Compartmentalized nitric oxide signaling in the resistance vasculature #MMPMID26028569 Mutchler SM; Straub AC Nitric Oxide 2015[Sep]; 49 (ä): 8-15 PMID26028569show ga Nitric oxide (NO) was first described as a bioactive molecule through its ability to stimulate soluble guanylate cyclase, but the revelation that NO was the endothelium derived relaxation factor drove the field to its modern state. The wealth of research conducted over the past 30 years has provided us with a picture of how diverse NO signaling can be within the vascular wall, going beyond simple vasodilation to include such roles as signaling through protein S-nitrosation. This expanded view of NO?s actions requires highly regulated and compartmentalized production. Importantly, resistance arteries house multiple proteins involved in the production and transduction of NO allowing for efficient movement of the molecule to regulate vascular tone and reactivity. In this review, we focus on the many mechanisms regulating NO production and signaling action in the vascular wall, with a focus on the control of endothelial nitric oxide synthase (eNOS), the enzyme responsible for synthesizing most of the NO within these confines. We also explore how cross talk between the endothelium and smooth muscle in the microcirculation can modulate NO signaling, illustrating that this one small molecule has the capability to produce a plethora of responses. äCompartmentalized nitric oxide signaling in the resistance vasculature(epmc).pdf DeepDyve Pubget Overpricing