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10.1097/NEN.0000000000000227 http://scihub22266oqcxt.onion/10.1097/NEN.0000000000000227 C4544656!4544656!26222502     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neuropathol+Exp+Neurol 2015 ; 74 (9): 889-900 Nephropedia Template TP {{tp|p=26222502|t=2015. Pharmacological WNT Inhibition Reduces Proliferation, Survival and Clonogenicity of Glioblastoma Cells |pdf=|usr=}}{{26222502}} gab.com Text Pharmacological WNT Inhibition Reduces Proliferation, Survival and Clonogenicity of Glioblastoma Cells JO: J Neuropathol Exp Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26222502 #FOAvip Wingless (WNT) signaling has been shown to be an important pathway in gliomagenesis and in the growth of stem-like glioma cells. Using immunohistochemistry to assess translocation of ?-catenin protein, we identified intranuclear staining, which suggest WNT pathway activation, in 8 of 43 (19%) adult and 9 of 30 (30%) pediatric glioblastoma patient surgical samples. WNT activity, evidenced by nuclear ?-catenin in our cohort and high expression of its target AXIN2 in published glioma datasets, was associated with shorter patient survival, although this was not statistically significant. We determined the effects of the porcupine inhibitor LGK974 in 3 glioblastoma cell lines with elevated AXIN2 and found that it reduced WNT pathway activity by 50% or more as assessed by T cell factor-luciferase reporters. WNT inhibition led to suppression of growth and proliferation in the cultures and a modest induction of cell death. LGK974 reduced NANOG mRNA levels and the fraction of cells expressing the stem cell marker CD133 in neurosphere cultures, induced glial differentiation, and suppressed clonogenicity. These data indicate that LGK974 represents a promising new agent that can inhibit the canonical WNT pathway in vitro, slow tumor growth and deplete stem-like clonogenic cells, thereby providing further support for targeting WNT in patients with glioblastoma. Twit Text FOAVip Pharmacological WNT Inhibition Reduces Proliferation, Survival and Clonogenicity of Glioblastoma Cells ????J Neuropathol Exp Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26222502 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26222502 #FOAvip English Wikipedia <ref>{{Cite pmid|26222502}}</ref> Pharmacological WNT Inhibition Reduces Proliferation, Survival and Clonogenicity of Glioblastoma Cells #MMPMID26222502 Kahlert UD; Suwala AK; Koch K; Natsumeda M; Orr BA; Hayashi M; Maciaczyk J; Eberhart CG J Neuropathol Exp Neurol 2015[Sep]; 74 (9): 889-900 PMID26222502show ga Wingless (WNT) signaling has been shown to be an important pathway in gliomagenesis and in the growth of stem-like glioma cells. Using immunohistochemistry to assess translocation of ?-catenin protein, we identified intranuclear staining, which suggest WNT pathway activation, in 8 of 43 (19%) adult and 9 of 30 (30%) pediatric glioblastoma patient surgical samples. WNT activity, evidenced by nuclear ?-catenin in our cohort and high expression of its target AXIN2 in published glioma datasets, was associated with shorter patient survival, although this was not statistically significant. We determined the effects of the porcupine inhibitor LGK974 in 3 glioblastoma cell lines with elevated AXIN2 and found that it reduced WNT pathway activity by 50% or more as assessed by T cell factor-luciferase reporters. WNT inhibition led to suppression of growth and proliferation in the cultures and a modest induction of cell death. LGK974 reduced NANOG mRNA levels and the fraction of cells expressing the stem cell marker CD133 in neurosphere cultures, induced glial differentiation, and suppressed clonogenicity. These data indicate that LGK974 represents a promising new agent that can inhibit the canonical WNT pathway in vitro, slow tumor growth and deplete stem-like clonogenic cells, thereby providing further support for targeting WNT in patients with glioblastoma. äPharmacological WNT Inhibition Reduces Proliferation, Survival and Clo(epmc).pdf DeepDyve Pubget Overpricing