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10.1097/NEN.0000000000000227 http://scihub22266oqcxt.onion/10.1097/NEN.0000000000000227 C4544656!4544656 !26222502     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26222502 &cmd=llinks): Failed to open stream: HTTP request failed! 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Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells |pdf=|usr=}}{{26222502 }} gab.com Text Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells JO: J Neuropathol Exp Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26222502 #FOAvip Wingless (Wnt) signaling is an important pathway in gliomagenesis and in the growth of stem-like glioma cells. Using immunohistochemistry to assess the translocation of ?-catenin protein, we identified intranuclear staining suggesting Wnt pathway activation in 8 of 43 surgical samples (19%) from adult patients with glioblastoma and in 9 of 30 surgical samples (30%) from pediatric patients with glioblastoma. Wnt activity, evidenced by nuclear ?-catenin in our cohort and high expression of its target AXIN2 (axis inhibitor protein 2) in published glioma datasets, was associated with shorter patient survival, although this was not statistically significant. We determined the effects of the porcupine inhibitor LGK974 on 3 glioblastoma cell lines with elevated AXIN2 and found that it reduced Wnt pathway activity by 50% or more, as assessed by T-cell factor luciferase reporters. Wnt inhibition led to suppression of growth, proliferation in cultures, and modest induction of cell death. LGK974 reduced NANOG messenger RNA levels and the fraction of cells expressing the stem cell marker CD133 in neurosphere cultures, induced glial differentiation, and suppressed clonogenicity. These data indicate that LGK974 is a promising new agent that can inhibit the canonical Wnt pathway in vitro, slow tumor growth, and deplete stem-like clonogenic cells, thereby providing further support for targeting Wnt in patients with glioblastoma. Twit Text FOAVip Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells ????J Neuropathol Exp Neurol http://www.kidney.de/pget.php?&tw=1&pmid=26222502 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26222502 #FOAvip English Wikipedia <ref>{{Cite pmid|26222502 }}</ref> Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells #MMPMID26222502 Kahlert UD ; Suwala AK ; Koch K ; Natsumeda M ; Orr BA ; Hayashi M ; Maciaczyk J ; Eberhart CG J Neuropathol Exp Neurol 2015[Sep]; 74 (9 ): 889-900 PMID26222502 show ga Wingless (Wnt) signaling is an important pathway in gliomagenesis and in the growth of stem-like glioma cells. Using immunohistochemistry to assess the translocation of ?-catenin protein, we identified intranuclear staining suggesting Wnt pathway activation in 8 of 43 surgical samples (19%) from adult patients with glioblastoma and in 9 of 30 surgical samples (30%) from pediatric patients with glioblastoma. Wnt activity, evidenced by nuclear ?-catenin in our cohort and high expression of its target AXIN2 (axis inhibitor protein 2) in published glioma datasets, was associated with shorter patient survival, although this was not statistically significant. We determined the effects of the porcupine inhibitor LGK974 on 3 glioblastoma cell lines with elevated AXIN2 and found that it reduced Wnt pathway activity by 50% or more, as assessed by T-cell factor luciferase reporters. Wnt inhibition led to suppression of growth, proliferation in cultures, and modest induction of cell death. LGK974 reduced NANOG messenger RNA levels and the fraction of cells expressing the stem cell marker CD133 in neurosphere cultures, induced glial differentiation, and suppressed clonogenicity. These data indicate that LGK974 is a promising new agent that can inhibit the canonical Wnt pathway in vitro, slow tumor growth, and deplete stem-like clonogenic cells, thereby providing further support for targeting Wnt in patients with glioblastoma. |Adult [MESH] |Brain Neoplasms/*genetics/pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects/*physiology [MESH] |Cell Survival/drug effects/physiology [MESH] |Child [MESH] |Glioblastoma/*genetics/pathology [MESH] |Humans [MESH] |Pyrazines/*pharmacology [MESH] |Pyridines/*pharmacology [MESH] |Tumor Stem Cell Assay/*methods [MESH]Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clon(epmc).pdf DeepDyve Pubget Overpricing