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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Head+Neck+Pathol
2015 ; 9
(3
): 334-44
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gab.com Text
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English Wikipedia
Parotid Gland Nodular Fasciitis: A Clinicopathologic Series of 12 Cases with a
Review of 18 Cases from the Literature
#MMPMID25472697
Gibson TC
; Bishop JA
; Thompson LD
Head Neck Pathol
2015[Sep]; 9
(3
): 334-44
PMID25472697
show ga
Nodular fasciitis (NF), very uncommon in the parotid gland, is a benign
myofibroblastic proliferation that may be mistaken for other neoplastic
proliferations. The mass-like clinical presentation and histologic features
result in frequent misclassification, resulting in inappropriate clinical
management. There are only a few reported cases in the English literature. Cases
within the files of the authors' institutions (retrospective) confined to the
parotid gland were compared to cases reported in the English literature (Medline
1966-2014). The patients included five females and seven males, aged 11-70 years
(mean 45.2 years). All patients presented with a mass lesion, present on average
1.9 months, without a documented history of trauma. The lesions were 0.7-5.2 cm
(mean 2.2 cm). Seven patients had fine needle aspiration. The majority of the
lesions were circumscribed (n = 9), composed of spindle-shaped to stellate
myofibroblasts (MF) arranged in a storiform growth pattern, juxtaposed to
hypocellular myxoid tissue-culture-like areas with extravasation of erythrocytes.
Dense, keloid-like collagen (n = 7) and occasional giant cells were seen (n = 6).
Mitotic figures (without atypical forms) were readily identifiable (mean 4/10
HPFs). By immunohistochemical staining, the MF were reactive with vimentin,
actins, and calponin, while the histiocytes were reactive with CD68. All patients
had surgical excision. One patient developed local recurrence (12 months later).
All were alive and disease free at last follow-up, with a mean 133 months of
follow-up. The principle differential diagnoses include fibrosarcoma,
fibromatosis, pleomorphic adenoma, myoepithelioma, neurofibroma, schwannoma,
solitary fibrous tumor, leiomyoma, fibrous histiocytoma and myxoma. NF of the
parotid gland occurs in middle-aged patients who present with a mass (mean 2.2
cm) in the parotid gland of short duration (1.9 months). FNA misinterpretation
frequently leads to excision. Separation from myoepithelial and mesenchymal
lesions affecting the parotid gland results in appropriate management.