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10.1016/j.celrep.2014.06.045 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.06.045 C4542310!4542310!25066122     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2014 ; 8 (3): 688-95 Nephropedia Template TP {{tp|p=25066122|t=2014. Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion |pdf=|usr=}}{{25066122}} gab.com Text Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25066122 #FOAvip Clonal selection and transcriptional reprogramming (e.g., epithelial-mesenchymal transition or phenotype switching) are the predominant theories thought to underlie tumor progression. However, a ?division of labor? leading to cooperation among tumor-cell subpopulations could be an additional catalyst of progression. Using a zebrafish-melanoma xenograft model, we found that in a heterogeneous setting, inherently invasive cells, which possess protease activity and deposit extracellular matrix (ECM), co-invade with subpopulations of poorly invasive cells, a phenomenon we term ?cooperative invasion?. Whereas the poorly invasive cells benefit from heterogeneity, the invasive cells switch from protease-independent to an MT1-MMP-dependent mode of invasion. We did not observe changes in expression of the melanoma phenotype determinant MITF during cooperative invasion, thus ruling out the necessity for phenotype switching for invasion. Altogether, our data suggest that cooperation can drive melanoma progression without the need for clonal selection or phenotype switching and can account for the preservation of heterogeneity seen throughout tumor progression. Twit Text FOAVip Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25066122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25066122 #FOAvip English Wikipedia <ref>{{Cite pmid|25066122}}</ref> Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion #MMPMID25066122 Chapman A; Fernandez del Ama L; Ferguson J; Kamarashev J; Wellbrock C; Hurlstone A Cell Rep 2014[Aug]; 8 (3): 688-95 PMID25066122show ga Clonal selection and transcriptional reprogramming (e.g., epithelial-mesenchymal transition or phenotype switching) are the predominant theories thought to underlie tumor progression. However, a ?division of labor? leading to cooperation among tumor-cell subpopulations could be an additional catalyst of progression. Using a zebrafish-melanoma xenograft model, we found that in a heterogeneous setting, inherently invasive cells, which possess protease activity and deposit extracellular matrix (ECM), co-invade with subpopulations of poorly invasive cells, a phenomenon we term ?cooperative invasion?. Whereas the poorly invasive cells benefit from heterogeneity, the invasive cells switch from protease-independent to an MT1-MMP-dependent mode of invasion. We did not observe changes in expression of the melanoma phenotype determinant MITF during cooperative invasion, thus ruling out the necessity for phenotype switching for invasion. Altogether, our data suggest that cooperation can drive melanoma progression without the need for clonal selection or phenotype switching and can account for the preservation of heterogeneity seen throughout tumor progression. äHeterogeneous Tumor Subpopulations Cooperate to Drive Invasion (epmc).pdf DeepDyve Pubget Overpricing