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10.1016/j.celrep.2014.11.033 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.11.033 C4542305!4542305!25497096     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2014 ; 9 (6): 2219-32 Nephropedia Template TP {{tp|p=25497096|t=2014. Rfx6 Maintains the Functional Identity of Adult Pancreatic ? Cells |pdf=|usr=}}{{25497096}} gab.com Text Rfx6 Maintains the Functional Identity of Adult Pancreatic Cells JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25497096 #FOAvip Increasing evidence suggests that loss of ? cell characteristics may cause insulin secretory deficiency in diabetes, but the underlying mechanisms remain unclear. Here, we show that Rfx6, whose mutation leads to neonatal diabetes in humans, is essential to maintain key features of functionally mature ? cells in mice. Rfx6 loss in adult ? cells leads to glucose intolerance, impaired ? cell glucose sensing, and defective insulin secretion. This is associated with reduced expression of core components of the insulin secretion pathway, including glucokinase, the Abcc8/SUR1 subunit of KATP channels and voltage-gated Ca2+ channels, which are direct targets of Rfx6. Moreover, Rfx6 contributes to the silencing of the vast majority of ?disallowed? genes, a group usually specifically repressed in adult ? cells, and thus to the maintenance of ? cell maturity. These findings raise the possibility that changes in Rfx6 expression or activity may contribute to ? cell failure in humans. Twit Text FOAVip Rfx6 Maintains the Functional Identity of Adult Pancreatic Cells ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25497096 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25497096 #FOAvip English Wikipedia <ref>{{Cite pmid|25497096}}</ref> Rfx6 Maintains the Functional Identity of Adult Pancreatic ? Cells #MMPMID25497096 Piccand J; Strasser P; Hodson D; Meunier A; Ye T; Keime C; Birling MC; Rutter G; Gradwohl G Cell Rep 2014[Dec]; 9 (6): 2219-32 PMID25497096show ga Increasing evidence suggests that loss of ? cell characteristics may cause insulin secretory deficiency in diabetes, but the underlying mechanisms remain unclear. Here, we show that Rfx6, whose mutation leads to neonatal diabetes in humans, is essential to maintain key features of functionally mature ? cells in mice. Rfx6 loss in adult ? cells leads to glucose intolerance, impaired ? cell glucose sensing, and defective insulin secretion. This is associated with reduced expression of core components of the insulin secretion pathway, including glucokinase, the Abcc8/SUR1 subunit of KATP channels and voltage-gated Ca2+ channels, which are direct targets of Rfx6. Moreover, Rfx6 contributes to the silencing of the vast majority of ?disallowed? genes, a group usually specifically repressed in adult ? cells, and thus to the maintenance of ? cell maturity. These findings raise the possibility that changes in Rfx6 expression or activity may contribute to ? cell failure in humans. äRfx6 Maintains the Functional Identity of Adult Pancreatic ? Cells (epmc).pdf DeepDyve Pubget Overpricing