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10.1016/j.celrep.2014.10.041 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.10.041 C4542304!4542304!25456137     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2014 ; 9 (4): 1482-94 Nephropedia Template TP {{tp|p=25456137|t=2014. The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA |pdf=|usr=}}{{25456137}} gab.com Text The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25456137 #FOAvip The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interferon induction and die by embryonic day E12.5. We demonstrate that Adar1 embryonic lethality is rescued to live birth in Adar1; Mavs double mutants in which the antiviral interferon induction response to cytoplasmic double-stranded RNA (dsRNA) is prevented. Aberrant immune responses in Adar1 mutant mouse embryo fibroblasts are dramatically reduced by restoring the expression of editing-active cytoplasmic ADARs. We propose that inosine in cellular RNA inhibits antiviral inflammatory and interferon responses by altering RLR interactions. Transfecting dsRNA oligonucleotides containing inosine-uracil base pairs into Adar1 mutant mouse embryo fibroblasts reduces the aberrant innate immune response. ADAR1 mutations causing AGS affect the activity of the interferon-inducible cytoplasmic isoform more severely than the nuclear isoform. Twit Text FOAVip The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=25456137 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25456137 #FOAvip English Wikipedia <ref>{{Cite pmid|25456137}}</ref> The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA #MMPMID25456137 Mannion N; Greenwood SM; Young R; Cox S; Brindle J; Read D; Nellåker C; Vesely C; Ponting C; McLaughlin P; Jantsch M; Dorin J; Adams I; Scadden A; Öhman M; Keegan L; O?Connell M Cell Rep 2014[Nov]; 9 (4): 1482-94 PMID25456137show ga The ADAR RNA-editing enzymes deaminate adenosine bases to inosines in cellular RNAs. Aberrant interferon expression occurs in patients in whom ADAR1 mutations cause Aicardi-Goutières syndrome (AGS) or dystonia arising from striatal neurodegeneration. Adar1 mutant mouse embryos show aberrant interferon induction and die by embryonic day E12.5. We demonstrate that Adar1 embryonic lethality is rescued to live birth in Adar1; Mavs double mutants in which the antiviral interferon induction response to cytoplasmic double-stranded RNA (dsRNA) is prevented. Aberrant immune responses in Adar1 mutant mouse embryo fibroblasts are dramatically reduced by restoring the expression of editing-active cytoplasmic ADARs. We propose that inosine in cellular RNA inhibits antiviral inflammatory and interferon responses by altering RLR interactions. Transfecting dsRNA oligonucleotides containing inosine-uracil base pairs into Adar1 mutant mouse embryo fibroblasts reduces the aberrant innate immune response. ADAR1 mutations causing AGS affect the activity of the interferon-inducible cytoplasmic isoform more severely than the nuclear isoform. äThe RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA (epmc).pdf DeepDyve Pubget Overpricing