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2015 ; 9
(9
): 2094-107
Nephropedia Template TP
gab.com Text
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English Wikipedia
Antarctic archaea-virus interactions: metaproteome-led analysis of invasion,
evasion and adaptation
#MMPMID26125682
Tschitschko B
; Williams TJ
; Allen MA
; Páez-Espino D
; Kyrpides N
; Zhong L
; Raftery MJ
; Cavicchioli R
ISME J
2015[Sep]; 9
(9
): 2094-107
PMID26125682
show ga
Despite knowledge that viruses are abundant in natural ecosystems, there is
limited understanding of which viruses infect which hosts, and how both hosts and
viruses respond to those interactions-interactions that ultimately shape
community structure and dynamics. In Deep Lake, Antarctica, intergenera gene
exchange occurs rampantly within the low complexity, haloarchaea-dominated
community, strongly balanced by distinctions in niche adaptation which maintain
sympatric speciation. By performing metaproteomics for the first time on
haloarchaea, genomic variation of S-layer, archaella and other cell surface
proteins was linked to mechanisms of infection evasion. CRISPR defense systems
were found to be active, with haloarchaea responding to at least eight distinct
types of viruses, including those infecting between genera. The role of BREX
systems in defending against viruses was also examined. Although evasion and
defense were evident, both hosts and viruses also may benefit from viruses
carrying and expressing host genes, thereby potentially enhancing genetic
variation and phenotypic differences within populations. The data point to a
complex inter-play leading to a dynamic optimization of host-virus interactions.
This comprehensive overview was achieved only through the integration of results
from metaproteomics, genomics and metagenomics.