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10.1016/j.bbamem.2015.02.012 http://scihub22266oqcxt.onion/10.1016/j.bbamem.2015.02.012 C4540701!4540701!25701234     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2015 ; 1848 (11 0 0): 3101-11 Nephropedia Template TP {{tp|p=25701234|t=2015. On the in vivo significance of bacterial resistance to antimicrobial peptides |pdf=|usr=}}{{25701234}} gab.com Text On the in vivo significance of bacterial resistance to antimicrobial peptides JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=25701234 #FOAvip Antimicrobial peptides (AMPs) are at the front-line of host defense during infection and play critical roles both in reducing the microbial load early during infection and in linking innate to adaptive immunity. However, successful pathogens have developed mechanisms to resist AMPs. Although considerable progress has been made in elucidating AMP-resistance mechanisms of pathogenic bacteria in vitro, less is known regarding the in vivo significance of such resistance. Nevertheless, progress has been made in this area, largely by using murine models and, in two instances, human models of infection. Herein, we review progress on the use of in vivo infection models in AMP research and discuss the AMP resistance mechanisms that have been established by in vivo studies to contribute to microbial infection. We posit that in vivo infection models are essential tools for investigators to understand the significance to pathogenesis of genetic changes that impact levels of bacterial susceptibility to AMPs. Twit Text FOAVip On the in vivo significance of bacterial resistance to antimicrobial peptides ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=25701234 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25701234 #FOAvip English Wikipedia <ref>{{Cite pmid|25701234}}</ref> On the in vivo significance of bacterial resistance to antimicrobial peptides #MMPMID25701234 Bauer ME; Shafer WM Biochim Biophys Acta 2015[Nov]; 1848 (11 0 0): 3101-11 PMID25701234show ga Antimicrobial peptides (AMPs) are at the front-line of host defense during infection and play critical roles both in reducing the microbial load early during infection and in linking innate to adaptive immunity. However, successful pathogens have developed mechanisms to resist AMPs. Although considerable progress has been made in elucidating AMP-resistance mechanisms of pathogenic bacteria in vitro, less is known regarding the in vivo significance of such resistance. Nevertheless, progress has been made in this area, largely by using murine models and, in two instances, human models of infection. Herein, we review progress on the use of in vivo infection models in AMP research and discuss the AMP resistance mechanisms that have been established by in vivo studies to contribute to microbial infection. We posit that in vivo infection models are essential tools for investigators to understand the significance to pathogenesis of genetic changes that impact levels of bacterial susceptibility to AMPs. äOn the in vivo significance of bacterial resistance to antimicrobial p(epmc).pdf DeepDyve Pubget Overpricing