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10.1016/j.addr.2015.02.007 http://scihub22266oqcxt.onion/10.1016/j.addr.2015.02.007 C4539950!4539950!25733311     free     free     free       Adv+Drug+Deliv+Rev 2015 ; 87 (ä): 68-80 Nephropedia Template TP {{tp|p=25733311|t=2015. Delivery of Oligonucleotides with Lipid Nanoparticles |pdf=|usr=}}{{25733311}} gab.com Text Delivery of Oligonucleotides with Lipid Nanoparticles JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=25733311 #FOAvip Since their inception in the 1980's, oligonucleotide-based (ON-based) therapeutics have been recognized as powerful tools that can treat a broad spectrum of diseases. The discoveries of novel regulatory methods of gene expression with diverse mechanisms of action are still driving the development of novel ON-based therapeutics. Difficulties in the delivery of this class of therapeutics hinder their in vivo applications, which forces drug delivery systems to be a prerequisite for clinical translation. This review discusses the strategy of using lipid nanoparticles as carriers to deliver therapeutic ONs to target cells in vitro and in vivo. A discourse on how chemical and physical properties of the lipid materials could be utilized during formulation and the resulting effects on delivery efficiency constitutes the major part of this review. Twit Text FOAVip Delivery of Oligonucleotides with Lipid Nanoparticles ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=25733311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25733311 #FOAvip English Wikipedia <ref>{{Cite pmid|25733311}}</ref> Delivery of Oligonucleotides with Lipid Nanoparticles #MMPMID25733311 Wang Y; Miao L; Satterlee A; Huang L Adv Drug Deliv Rev 2015[Jun]; 87 (ä): 68-80 PMID25733311show ga Since their inception in the 1980's, oligonucleotide-based (ON-based) therapeutics have been recognized as powerful tools that can treat a broad spectrum of diseases. The discoveries of novel regulatory methods of gene expression with diverse mechanisms of action are still driving the development of novel ON-based therapeutics. Difficulties in the delivery of this class of therapeutics hinder their in vivo applications, which forces drug delivery systems to be a prerequisite for clinical translation. This review discusses the strategy of using lipid nanoparticles as carriers to deliver therapeutic ONs to target cells in vitro and in vivo. A discourse on how chemical and physical properties of the lipid materials could be utilized during formulation and the resulting effects on delivery efficiency constitutes the major part of this review. äDelivery of Oligonucleotides with Lipid Nanoparticles (epmc).pdf DeepDyve Pubget Overpricing