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2015 ; 15
(7
): e29052
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Efficacy of Hepatoprotective Agents With or Without Antiviral Drugs on Liver
Function and Fibrosis in Patients With Hepatitis B: A Meta-Analysis
#MMPMID26300933
Long LH
; Xue CQ
; Shi JF
; Dong JN
; Wang L
Hepat Mon
2015[Jul]; 15
(7
): e29052
PMID26300933
show ga
CONTEXT: To systematically evaluate the effects of hepatoprotective agents, when
delivered either alone or in combination with other antiviral or non-antiviral
drugs in patients with hepatitis B and hepatic fibrosis. OBJECTIVES: The current
randomized controlled clinical trials aimed to evaluate the efficacy of
combinations of antiviral and non-antiviral hepatoprotective agents on indexes of
liver function and liver fibrosis in patients with hepatitis B. DATA SOURCES:
Published literatures in Chinese and English on hepatoprotective treatment
strategies for chronic hepatitis B and liver fibrosis were searched in three
databases and randomized controlled clinical trials were selected. STUDY
SELECTION: Data were extracted according to a variety of inclusion and exclusion
criteria. Meta-analysis was employed to analyze the data. RESULTS: A total of 22
randomized controlled trials encompassing 1,714 cases were considered in the
meta-analysis. The obtained results indicated that the combination of antiviral
drug and hepatoprotective agent was better than antiviral drug alone to improve
liver function. Similarly, regarding liver fibrosis, using two different
hepatoprotective agents was better than using one agent. The normalization rates
of Aminotransferase (ALT) and total Bilirubin (TBil) were improved 25.7% by two
hepatoprotective agents compared to the single agent. Acetylcysteine was superior
to ursodeoxycholic acid or silibinin to reduce ALT. Ursodeoxycholic acid was
superior to acetylcysteine or silibinin to reduce TBIL. CONCLUSIONS:
Hepatoprotective agents combined with antiviral drugs can significantly improve
liver function and liver fibrosis parameters in patients with hepatitis B.