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2015 ; 10
(2
): 136-40
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Comparison of Serum Autoantibodies to Desmogleins I, III in Patients with Oral
Lichen Planus and Healthy Controls
#MMPMID26351474
Gholizadeh N
; Khoini Poorfar H
; TaghaviZenouz A
; Vatandoost M
; Mehdipour M
Iran J Pathol
2015[Spr]; 10
(2
): 136-40
PMID26351474
show ga
BACKGROUND & OBJECTIVE: Lichen planus is a mucocutaneous disease which is
relatively common and in 30-70% of patients, mucosal lesions can be seen and
known as a precancerous lesion but its etiology is not completely understood.
Desmogleins I and III are the main desmosomal transmembrane proteins. These
proteins have been identified as the autoantigen of the autoimmune disease. The
aim of this study was evaluation of serum autoantibodies against desmogleins ?,
??? in oral lichen planus . METHODS: We attempted to determine the etiology of
this disease with evaluation of these serum factors. Thirty-five patients with
oral lichen planus and 35 healthy controls were recruited and tested for serum
autoantibodies against desmogleins ?, ??? and indirect immunofluorescence also
performed. Data were analyzed by statistical-analytical methods (Independent
sample t -test) with using the SPSS.15 software. RESULTS: Serum autoantibody
against desmoglein ? had no significant difference in the two groups ( P =0.31 )
but significant increase in serum autoantibody to desmoglein ??? was found in
patients with oral lichen planus ( P =0.00) . CONCLUSION: It seems that
autoantibody against desmoglein III has a significant role in the pathogenesis of
oral lichen planus.