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10.1016/j.bbamem.2015.02.010

http://scihub22266oqcxt.onion/10.1016/j.bbamem.2015.02.010
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C4539303!4539303!25701232
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suck abstract from ncbi


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pmid25701232      Biochim+Biophys+Acta 2015 ; 1848 (11 0 0): 3047-54
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  • Cationic Antimicrobial Peptide Resistance Mechanisms of Streptococcal Pathogens #MMPMID25701232
  • LaRock CN; Nizet V
  • Biochim Biophys Acta 2015[Nov]; 1848 (11 0 0): 3047-54 PMID25701232show ga
  • Cationic antimicrobial peptides (CAMPs) are critical front line contributors to host defense against invasive bacterial infection. These immune factors have direct killing activity toward microbes, but many pathogens are able to resist their effects. Group A Streptococcus, group B Streptococcus and Streptococcus pneumoniae are among the most common pathogens of humans and display a variety of phenotypic adaptations to resist CAMPs. Common themes of CAMP resistance mechanisms among the pathogenic streptococci are repulsion, sequestration, export, and destruction. Each pathogen has a different array of CAMP-resistant mechanisms, with invasive disease potential reflecting the utilization of several mechanisms that may act in synergy. Here we discuss recent progress in identifying the sources of CAMP resistance in the medically important Streptococcus genus. Further study of these mechanisms can contribute to our understanding of streptococcal pathogenesis, and may provide new therapeutic targets for therapy and disease prevention.
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