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2015 ; 2015
(ä): 785705
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Serum IL-6 and IL-23 Levels and Their Correlation with Angiogenic Cytokines and
Disease Activity in Ankylosing Spondylitis, Psoriatic Arthritis, and SAPHO
Syndrome
#MMPMID26339141
Przepiera-B?dzak H
; Fischer K
; Brzosko M
Mediators Inflamm
2015[]; 2015
(ä): 785705
PMID26339141
show ga
OBJECTIVES: To assess serum interleukin-6 (IL-6) and interleukin-23 (IL-23) and
their correlation with angiogenic cytokines and disease activity in ankylosing
spondylitis (AS), psoriatic arthritis (PsA), and SAPHO syndrome. PATIENTS AND
METHODS: We studied 152 spondyloarthritis (SpA) patients: 69 PsA, 61 AS, 22
SAPHO, and 29 controls. We recorded age, sex, disease duration, and treatment. We
assessed BASDAI, VAS, and PASI scores. Serum IL-6, IL-23, VEGF, EGF, FGFb, and
FGFa levels were determined using ELISA. We estimated ESR and CRP. RESULTS: Serum
IL-6 and IL-23 levels were higher in SpA than in control (P < 0.00001 and P =
0.0004, resp.). There was a positive correlation between serum IL-6 and CRP in AS
(P = 0.000001), PsA (P = 0.000001), and SAPHO (P = 0.0003) patients. There was a
positive correlation between serum IL-6 and ESR in AS (P = 0.000001), PsA (P =
0.002), and SAPHO (P = 0.02) patients. There was no correlation of serum IL-6 and
IL-23 with VAS, BASDAI, and angiogenic cytokines in SpA. CONCLUSIONS: Serum IL-6
but not serum IL-23 correlated with ESR and CRP in SpA. No correlation was found
of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines.