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10.1155/2015/896432 http://scihub22266oqcxt.onion/10.1155/2015/896432 C4538961!4538961!26339650     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2015 ; 2015 (ä): ä Nephropedia Template TP {{tp|p=26339650|t=2015. hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers |pdf=|usr=}}{{26339650}} gab.com Text hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26339650 #FOAvip Because of their high incidence and mortality solid cancers are a major health problem worldwide. Although several new biomarkers and potential targets for therapy have been identified through biomolecular research in the last years, the effects on patients' outcome are still unsatisfactory. Increasing evidence indicates that hERG1 potassium channels are overexpressed in human primary cancers of different origin and several associations between hERG1 expression and clinicopathological features and/or outcome are emerging. Aberrant hERG1 expression may be exploited either for early diagnosis (especially in those cancers where it is expressed in the initial steps of tumor progression) or for therapy purposes. Indeed, hERG1 blockage impairs tumor cell growth both in vitro and in vivo in preclinical mouse model. hERG1-based tumor therapy in humans, however, encounters the major hindrance of the potential cardiotoxicity that many hERG1 blockers exert. In this review we focus on recent advances in translational research in some of the most frequent human solid cancers (breast, endometrium, ovary, pancreas, esophagus, stomach, and colorectum) that have been shown to express hERG1 and that are a major health problem. Twit Text FOAVip hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=26339650 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26339650 #FOAvip English Wikipedia <ref>{{Cite pmid|26339650}}</ref> hERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers #MMPMID26339650 Lastraioli E; Lottini T; Bencini L; Bernini M; Arcangeli A Biomed Res Int 2015[]; 2015 (ä): ä PMID26339650show ga Because of their high incidence and mortality solid cancers are a major health problem worldwide. Although several new biomarkers and potential targets for therapy have been identified through biomolecular research in the last years, the effects on patients' outcome are still unsatisfactory. Increasing evidence indicates that hERG1 potassium channels are overexpressed in human primary cancers of different origin and several associations between hERG1 expression and clinicopathological features and/or outcome are emerging. Aberrant hERG1 expression may be exploited either for early diagnosis (especially in those cancers where it is expressed in the initial steps of tumor progression) or for therapy purposes. Indeed, hERG1 blockage impairs tumor cell growth both in vitro and in vivo in preclinical mouse model. hERG1-based tumor therapy in humans, however, encounters the major hindrance of the potential cardiotoxicity that many hERG1 blockers exert. In this review we focus on recent advances in translational research in some of the most frequent human solid cancers (breast, endometrium, ovary, pancreas, esophagus, stomach, and colorectum) that have been shown to express hERG1 and that are a major health problem. ähERG1 Potassium Channels: Novel Biomarkers in Human Solid Cancers (epmc).pdf DeepDyve Pubget Overpricing