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2015 ; 2015
(ä): 194031
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Genotoxic Effect in Autoimmune Diseases Evaluated by the Micronucleus Test Assay:
Our Experience and Literature Review
#MMPMID26339592
Torres-Bugarín O
; Macriz Romero N
; Ramos Ibarra ML
; Flores-García A
; Valdez Aburto P
; Zavala-Cerna MG
Biomed Res Int
2015[]; 2015
(ä): 194031
PMID26339592
show ga
Autoimmune diseases (AD) are classified into organ-specific, systemic, and mixed;
all forms of AD share a high risk for cancer development. In AD a destructive
immune response induced by autoreactive lymphocytes is started and continues with
the production of autoantibodies against different targets; furthermore apoptosis
failure and loss of balance in oxidative stress as a consequence of local or
systemic inflammation are common features seen in AD as well. Micronucleus (MN)
assay can be performed in order to evaluate loss of genetic material in a clear,
accurate, fast, simple, and minimally invasive test. The MN formation in the
cytoplasm of cells that have undergone proliferation is a consequence of DNA
fragmentation during mitosis and the appearance of small additional nuclei during
interphase. The MN test, widely accepted for in vitro and in vivo genotoxicity
research, provides a sensitive marker of genomic damage associated to diverse
conditions. In here, we present a review of our work and other published papers
concerning genotoxic effect in AD, identified by means of the MN assay, with the
aim of proposing this tool as a possible early biomarker for genotoxic damage,
which is a consequence of disease progression. Additionally this biomarker could
be used for follow-up, to asses genome damage associated to therapies.
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