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Effect of Dietary ?-3 Polyunsaturated Fatty Acid DHA on Glycolytic Enzymes and
Warburg Phenotypes in Cancer
#MMPMID26339588
Manzi L
; Costantini L
; Molinari R
; Merendino N
Biomed Res Int
2015[]; 2015
(?): 137097
PMID26339588
show ga
The omega-3 polyunsaturated fatty acids (?-3 PUFAs) are a class of lipids that
has been shown to have beneficial effects on some chronic degenerative diseases
such as cardiovascular diseases, rheumatoid arthritis, inflammatory disorders,
diabetes, and cancer. Among ?-3 polyunsaturated fatty acids (PUFAs),
docosahexaenoic acid (DHA) has received particular attention for its
antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and
antimetastatic properties, even though the involved molecular mechanisms are not
well understood. Recently, some in vitro studies showed that DHA promotes the
inhibition of glycolytic enzymes and the Warburg phenotype. For example, it was
shown that in breast cancer cell lines the modulation of bioenergetic functions
is due to the capacity of DHA to activate the AMPK signalling and negatively
regulate the HIF-1? functions. Taking into account these considerations, this
review is focused on current knowledge concerning the role of DHA in interfering
with cancer cell metabolism; this could be considered a further mechanism by
which DHA inhibits cancer cell survival and progression.
|*Diet
[MESH]
|AMP-Activated Protein Kinases/biosynthesis
[MESH]
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