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10.1016/j.bbmt.2015.05.015 http://scihub22266oqcxt.onion/10.1016/j.bbmt.2015.05.015 C4537838!4537838 !26028505     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26028505 &cmd=llinks): Failed to open stream: HTTP request failed! 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Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides for Treatment of Persistent Cytomegalovirus Infection or Viremia |pdf=|usr=}}{{26028505 }} gab.com Text Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides for Treatment of Persistent Cytomegalovirus Infection or Viremia JO: Biol Blood Marrow Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26028505 #FOAvip We conducted a phase I trial of allogeneic T cells sensitized in vitro against a pool of pentadecapeptides (15-mer peptides) spanning the sequence of CMVpp65 for adoptive therapy of 17 allogeneic hematopoietic cell transplant recipients with cytomegalovirus (CMV) viremia or clinical infection persisting despite prolonged treatment with antiviral drugs. All but 3 of the patients had received T cell-depleted transplants without graft-versus-host disease (GVHD) prophylaxis with immunosuppressive drugs after transplantation. The CMVpp65-specific T cells (CMVpp65CTLs) generated were oligoclonal and specific for only 1 to 3 epitopes, presented by a limited set of HLA class I or II alleles. T cell infusions were well tolerated without toxicity or GVHD. Of 17 patients treated with transplant donor (n = 16) or third-party (n = 1) CMVpp65CTLs, 15 cleared viremia, including 3 of 5 with overt disease. In responding patients, the CMVpp65CTLs infused consistently proliferated and could be detected by T cell receptor V? usage in CMVpp65/HLA tetramer + populations for period of 120 days to up to 2 years after infusion. Thus, CMVpp65CTLs generated in response to synthetic 15-mer peptides of CMVpp65 are safe and can clear persistent CMV infections in the post-transplantation period. Twit Text FOAVip Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides for Treatment of Persistent Cytomegalovirus Infection or Viremia ????Biol Blood Marrow Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26028505 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26028505 #FOAvip English Wikipedia <ref>{{Cite pmid|26028505 }}</ref> Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadecapeptides for Treatment of Persistent Cytomegalovirus Infection or Viremia #MMPMID26028505 Koehne G ; Hasan A ; Doubrovina E ; Prockop S ; Tyler E ; Wasilewski G ; O'Reilly RJ Biol Blood Marrow Transplant 2015[Sep]; 21 (9 ): 1663-78 PMID26028505 show ga We conducted a phase I trial of allogeneic T cells sensitized in vitro against a pool of pentadecapeptides (15-mer peptides) spanning the sequence of CMVpp65 for adoptive therapy of 17 allogeneic hematopoietic cell transplant recipients with cytomegalovirus (CMV) viremia or clinical infection persisting despite prolonged treatment with antiviral drugs. All but 3 of the patients had received T cell-depleted transplants without graft-versus-host disease (GVHD) prophylaxis with immunosuppressive drugs after transplantation. The CMVpp65-specific T cells (CMVpp65CTLs) generated were oligoclonal and specific for only 1 to 3 epitopes, presented by a limited set of HLA class I or II alleles. T cell infusions were well tolerated without toxicity or GVHD. Of 17 patients treated with transplant donor (n = 16) or third-party (n = 1) CMVpp65CTLs, 15 cleared viremia, including 3 of 5 with overt disease. In responding patients, the CMVpp65CTLs infused consistently proliferated and could be detected by T cell receptor V? usage in CMVpp65/HLA tetramer + populations for period of 120 days to up to 2 years after infusion. Thus, CMVpp65CTLs generated in response to synthetic 15-mer peptides of CMVpp65 are safe and can clear persistent CMV infections in the post-transplantation period. |*Cytomegalovirus Infections/immunology/pathology/therapy [MESH] |*Hematopoietic Stem Cell Transplantation [MESH] |*Lymphocyte Transfusion [MESH] |*T-Lymphocytes/immunology/pathology/transplantation [MESH] |*Tissue Donors [MESH] |*Viremia/immunology/pathology/therapy [MESH] |Aged [MESH] |Allografts [MESH] |Child [MESH] |Cytomegalovirus/*immunology [MESH] |Female [MESH] |Graft vs Host Disease/immunology/pathology/prevention & control [MESH] |Hematologic Neoplasms/immunology/pathology/therapy [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Peptides/*immunology/pharmacology [MESH] |Phosphoproteins/*immunology/pharmacology [MESH]Immunotherapy with Donor T Cells Sensitized with Overlapping Pentadeca(epmc).pdf DeepDyve Pubget Overpricing