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10.1038/srep13210 http://scihub22266oqcxt.onion/10.1038/srep13210 C4536490!4536490!26272053     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26272053&cmd=llinks): Failed to open stream: HTTP request failed! 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Evolutionary conservation analysis between the essential and nonessential genes in bacterial genomes |pdf=|usr=}}{{26272053}} gab.com Text Evolutionary conservation analysis between the essential and nonessential genes in bacterial genomes JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26272053 #FOAvip Essential genes are thought to be critical for the survival of the organisms under certain circumstances, and the natural selection acting on essential genes is expected to be stricter than on nonessential ones. Up to now, essential genes have been identified in approximately thirty bacterial organisms by experimental methods. In this paper, we performed a comprehensive comparison between the essential and nonessential genes in the genomes of 23 bacterial species based on the Ka/Ks ratio, and found that essential genes are more evolutionarily conserved than nonessential genes in most of the bacteria examined. Furthermore, we also analyzed the conservation by functional clusters with the clusters of orthologous groups (COGs), and found that the essential genes in the functional categories of G (Carbohydrate transport and metabolism), H (Coenzyme transport and metabolism), I (Transcription), J (Translation, ribosomal structure and biogenesis), K (Lipid transport and metabolism) and L (Replication, recombination and repair) tend to be more evolutionarily conserved than the corresponding nonessential genes in bacteria. The results suggest that the essential genes in these subcategories are subject to stronger selective pressure than the nonessential genes, and therefore, provide more insights of the evolutionary conservation for the essential and nonessential genes in complex biological processes. Twit Text FOAVip Evolutionary conservation analysis between the essential and nonessential genes in bacterial genomes ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26272053 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26272053 #FOAvip English Wikipedia <ref>{{Cite pmid|26272053}}</ref> Evolutionary conservation analysis between the essential and nonessential genes in bacterial genomes #MMPMID26272053 Luo H; Gao F; Lin Y Sci Rep 2015[]; 5 (ä): ä PMID26272053show ga Essential genes are thought to be critical for the survival of the organisms under certain circumstances, and the natural selection acting on essential genes is expected to be stricter than on nonessential ones. Up to now, essential genes have been identified in approximately thirty bacterial organisms by experimental methods. In this paper, we performed a comprehensive comparison between the essential and nonessential genes in the genomes of 23 bacterial species based on the Ka/Ks ratio, and found that essential genes are more evolutionarily conserved than nonessential genes in most of the bacteria examined. Furthermore, we also analyzed the conservation by functional clusters with the clusters of orthologous groups (COGs), and found that the essential genes in the functional categories of G (Carbohydrate transport and metabolism), H (Coenzyme transport and metabolism), I (Transcription), J (Translation, ribosomal structure and biogenesis), K (Lipid transport and metabolism) and L (Replication, recombination and repair) tend to be more evolutionarily conserved than the corresponding nonessential genes in bacteria. The results suggest that the essential genes in these subcategories are subject to stronger selective pressure than the nonessential genes, and therefore, provide more insights of the evolutionary conservation for the essential and nonessential genes in complex biological processes. äEvolutionary conservation analysis between the essential and nonessent(epmc).pdf DeepDyve Pubget Overpricing