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10.1097/MOP.0000000000000191 http://scihub22266oqcxt.onion/10.1097/MOP.0000000000000191 C4535724!4535724 !25635586     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25635586 &cmd=llinks): Failed to open stream: HTTP request failed! 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Developmental origins of health and disease: a paradigm for understanding disease cause and prevention |pdf=|usr=}}{{25635586 }} gab.com Text Developmental origins of health and disease: a paradigm for understanding disease cause and prevention JO: Curr Opin Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=25635586 #FOAvip PURPOSE OF REVIEW: Although diseases may appear clinically throughout the lifespan, it is clear that many diseases have origins during development. Altered nutrition, as well as exposure to environmental chemicals, drugs, infections, or stress during specific times of development, can lead to functional changes in tissues, predisposing those tissues to diseases that manifest later in life. This review will focus on the role of altered nutrition and exposures to environmental chemicals during development in the role of disease and dysfunction. RECENT FINDINGS: The effects of altered nutrition or exposure to environmental chemicals during development are likely because of altered programming of epigenetic marks, which persist across the lifespan. Indeed some changes can be transmitted to future generations. SUMMARY: The evidence in support of the developmental origins of the health and disease paradigm is sufficiently robust and repeatable across species, including humans, to suggest a need for greater emphasis in the clinical area. As a result of these data, obesity, diabetes, cardiovascular morbidity, and neuropsychiatric diseases can all be considered pediatric diseases. Disease prevention must start with improved nutrition and reduced exposure to environmental chemicals during development. Twit Text FOAVip Developmental origins of health and disease: a paradigm for understanding disease cause and prevention ????Curr Opin Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=25635586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25635586 #FOAvip English Wikipedia <ref>{{Cite pmid|25635586 }}</ref> Developmental origins of health and disease: a paradigm for understanding disease cause and prevention #MMPMID25635586 Heindel JJ ; Vandenberg LN Curr Opin Pediatr 2015[Apr]; 27 (2 ): 248-53 PMID25635586 show ga PURPOSE OF REVIEW: Although diseases may appear clinically throughout the lifespan, it is clear that many diseases have origins during development. Altered nutrition, as well as exposure to environmental chemicals, drugs, infections, or stress during specific times of development, can lead to functional changes in tissues, predisposing those tissues to diseases that manifest later in life. This review will focus on the role of altered nutrition and exposures to environmental chemicals during development in the role of disease and dysfunction. RECENT FINDINGS: The effects of altered nutrition or exposure to environmental chemicals during development are likely because of altered programming of epigenetic marks, which persist across the lifespan. Indeed some changes can be transmitted to future generations. SUMMARY: The evidence in support of the developmental origins of the health and disease paradigm is sufficiently robust and repeatable across species, including humans, to suggest a need for greater emphasis in the clinical area. As a result of these data, obesity, diabetes, cardiovascular morbidity, and neuropsychiatric diseases can all be considered pediatric diseases. Disease prevention must start with improved nutrition and reduced exposure to environmental chemicals during development. |*Epigenomics [MESH] |*Public Health [MESH] |Child [MESH] |Environmental Exposure/*adverse effects [MESH] |Environmental Pollutants/*toxicity [MESH] |Female [MESH] |Gene-Environment Interaction [MESH] |Humans [MESH] |Male [MESH] |Nutritional Physiological Phenomena [MESH] |Pregnancy [MESH]Developmental origins of health and disease: a paradigm for understand(epmc).pdf DeepDyve Pubget Overpricing