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1989 ; 4
(2
): 136-41
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Natural history and prognostic factors of primary hepatocellular carcinoma: study
of 70 untreated patients
#MMPMID2562101
Kim UB
; Doo CJ
; Baek SH
; Kim JH
; Lee HB
; Park SK
; Byun JH
Korean J Intern Med
1989[Jul]; 4
(2
): 136-41
PMID2562101
show ga
We carried out a study of the clinical courses of 70 untreated patients with
primary hepatocellular carcinoma (HCC) in order to evaluate their survival period
and the prognostic factors. The median survival was two months. We evaluated ten
variables of biochemical parameters and findings of hepatic scintigraphy. Among
them, six variables were chosen by univariate analysis. They were serum bilirubin
(cut-off value 3.0 mg/dl), alkaline phosphatase (150 IU/ml), aspartate
aminotransferase (AST) (200 IU/ml), alanine aminotransferase (ALT) (50 IU/ml),
reticuloendothelial (RES) dysfunction (grade 1) and multiplicity of space
occupying lesions (SOL). Multivariate analysis identified three variables. The
RES dysfunction and multiplicity of SOL by hepatic scintigraphy and bilirubin
were considered as important prognostic factors. We found that the functional
reservoir of the underlying liver and multiplicity of the origin of the tumor
were the most important prognostic factors.