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1987 ; 2
(2
): 234-48
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Subepidermal capillary basement membrane thickness of the skin obtained by punch
biopsy in patients with non insulin dependent diabetes mellitus
#MMPMID3154836
Bae HY
; Oh KT
; Chae JK
; Chung CH
; Hong SP
; Cho KK
Korean J Intern Med
1987[Jul]; 2
(2
): 234-48
PMID3154836
show ga
Thickening and proliferation of the capillary basement membrane is a generalized
phenomenon in diabetes mellitus and has been described in many organs including
the heart, kidney, pancreas, retina etc. While such changes are specific, it is
difficult to obtain specimens from those organs. Tissue samples were obtained
from the medial surface of the thigh of 33 diabetics and 4 healthy controls by
means of punch biopsy. Measurements carried out by normogram obtained from
electron microscopic pictures. HbA1c values were also determined at time of
muscle biopsy. 1. The HbA1c values are higher in diabetics than in the control
group (p<0.01). 2. The subepidermal capillary basement membrane thickness of the
diabetics: 30% of the 5?th decade population, 53.9% of the 6?th decade population
and 83.3% of the 7?th decade population was greater than 3,000 A°. Whereas that
of the controls was less than 3,000 A°. 3. The subepidermal capillary basement
membrane thickness was not significantly increased with the duration of the
disease. 4. In cases of greater subepidermal capillary besement membrane
thickness, HbA1c showed a significant increase. (p<0.01).
|Adult
[MESH]
|Aged
[MESH]
|Basement Membrane/pathology
[MESH]
|Blood Glucose/metabolism
[MESH]
|Capillaries/*pathology
[MESH]
|Diabetes Mellitus, Type 2/blood/*pathology
[MESH]