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10.1007/s00412-015-0507-z http://scihub22266oqcxt.onion/10.1007/s00412-015-0507-z C4534358!4534358!25670395     free     free     free       Chromosoma 2015 ; 124 (3): 323-31 Nephropedia Template TP {{tp|p=25670395|t=2015. Determinants of Mammalian Nucleolar Architecture |pdf=|usr=}}{{25670395}} gab.com Text Determinants of Mammalian Nucleolar Architecture JO: Chromosoma http://www.kidney.de/pget.php?&tw=1&pmid=25670395 #FOAvip The nucleolus is responsible for the production of ribosomes, essential machines which synthesize all proteins needed by the cell. The structure of human nucleoli is highly dynamic and is directly related to its functions in ribosome biogenesis. Despite the importance of this organelle, the intricate relationship between nucleolar structure and function remains largely unexplored. How do cells control nucleolar formation and function? What are the minimal requirements for making a functional nucleolus? Here we review what is currently known regarding mammalian nucleolar formation at nucleolar organizer regions (NORs), which can be studied by observing the dissolution and reformation of the nucleolus during each cell division. Additionally, the nucleolus can be examined by analyzing how alterations in nucleolar function manifest in differences in nucleolar architecture. Furthermore, changes in nucleolar structure and function are correlated with cancer, highlighting the importance of studying the determinants of nucleolar formation. Twit Text FOAVip Determinants of Mammalian Nucleolar Architecture ????Chromosoma http://www.kidney.de/pget.php?&tw=1&pmid=25670395 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25670395 #FOAvip English Wikipedia <ref>{{Cite pmid|25670395}}</ref> Determinants of Mammalian Nucleolar Architecture #MMPMID25670395 Farley KI; Surovtseva Y; Merkel J; Baserga SJ Chromosoma 2015[Sep]; 124 (3): 323-31 PMID25670395show ga The nucleolus is responsible for the production of ribosomes, essential machines which synthesize all proteins needed by the cell. The structure of human nucleoli is highly dynamic and is directly related to its functions in ribosome biogenesis. Despite the importance of this organelle, the intricate relationship between nucleolar structure and function remains largely unexplored. How do cells control nucleolar formation and function? What are the minimal requirements for making a functional nucleolus? Here we review what is currently known regarding mammalian nucleolar formation at nucleolar organizer regions (NORs), which can be studied by observing the dissolution and reformation of the nucleolus during each cell division. Additionally, the nucleolus can be examined by analyzing how alterations in nucleolar function manifest in differences in nucleolar architecture. Furthermore, changes in nucleolar structure and function are correlated with cancer, highlighting the importance of studying the determinants of nucleolar formation. äDeterminants of Mammalian Nucleolar Architecture (epmc).pdf DeepDyve Pubget Overpricing