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10.1002/ana.24295 http://scihub22266oqcxt.onion/10.1002/ana.24295 C4534165!4534165!25363147     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Neurol 2014 ; 76 (6): 911-5 Nephropedia Template TP {{tp|p=25363147|t=2014. Pediatric Super-Refractory Status Epilepticus Treated with Allopregnanolone |pdf=|usr=}}{{25363147}} gab.com Text Pediatric Super-Refractory Status Epilepticus Treated with Allopregnanolone JO: Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=25363147 #FOAvip Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic ?-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors. Here we describe the use of allopregnanolone in 2 pediatric patients with super-refractory status epilepticus. This treatment allowed the general anesthetic infusions to be weaned with resolution of status epilepticus. This is the first report of allopregnanolone use to treat status epilepticus in children. Twit Text FOAVip Pediatric Super-Refractory Status Epilepticus Treated with Allopregnanolone ????Ann Neurol http://www.kidney.de/pget.php?&tw=1&pmid=25363147 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25363147 #FOAvip English Wikipedia <ref>{{Cite pmid|25363147}}</ref> Pediatric Super-Refractory Status Epilepticus Treated with Allopregnanolone #MMPMID25363147 Broomall E; Natale JE; Grimason M; Goldstein J; Smith CM; Chang C; Kanes S; Rogawski MA; Wainwright MS Ann Neurol 2014[Dec]; 76 (6): 911-5 PMID25363147show ga Super-refractory status epilepticus is a life-threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic ?-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence. The neurosteroid allopregnanolone acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors. Here we describe the use of allopregnanolone in 2 pediatric patients with super-refractory status epilepticus. This treatment allowed the general anesthetic infusions to be weaned with resolution of status epilepticus. This is the first report of allopregnanolone use to treat status epilepticus in children. äPediatric Super-Refractory Status Epilepticus Treated with Allopregnan(epmc).pdf DeepDyve Pubget Overpricing