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10.1016/j.cellimm.2015.03.010 http://scihub22266oqcxt.onion/10.1016/j.cellimm.2015.03.010 C4533996!4533996!25863744     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Immunol 2015 ; 295 (2): 83-91 Nephropedia Template TP {{tp|p=25863744|t=2015. Chlamydia pneumoniae Promotes Dysfunction of Pancreatic Beta Cells |pdf=|usr=}}{{25863744}} gab.com Text Chlamydia pneumoniae Promotes Dysfunction of Pancreatic Beta Cells JO: Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25863744 #FOAvip The human pathogen Chlamydia pneumoniae has been implicated in chronic inflammatory diseases including type 2 diabetes. Therefore, we designed a study to evaluate pancreatic beta cells and mast cells during chlamydial infection. Our study revealed that C. pneumoniae infected mast cells significantly (p< 0.005) decreased beta cell ATP and insulin production, in contrast to uninfected mast cells co-cultured with beta cells. Infected mast cells exhibited pyknotic nuclei and active caspase-3 and caspase-1 expression. Additionally, ex vivo analyses of tissues collected from C. pneumoniae infected mice showed increased interleukin-1? production in splenocytes and pancreatic tissues as was observed with in vitro mast cell-beta cell co-cultures during C. pneumoniae infection. Notably, infected mast cells promoted beta cell destruction. Our findings reveal the negative effect of C. pneumoniae on mast cells, and the consequential impact on pancreatic beta cell function and viability. Twit Text FOAVip Chlamydia pneumoniae Promotes Dysfunction of Pancreatic Beta Cells ????Cell Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25863744 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25863744 #FOAvip English Wikipedia <ref>{{Cite pmid|25863744}}</ref> Chlamydia pneumoniae Promotes Dysfunction of Pancreatic Beta Cells #MMPMID25863744 Rodriguez AR; Plascencia-Villa G; Witt CM; Yu JJ; José-Yacamán M; Chambers JP; Perry G; Guentzel MN; Arulanandam BP Cell Immunol 2015[Jun]; 295 (2): 83-91 PMID25863744show ga The human pathogen Chlamydia pneumoniae has been implicated in chronic inflammatory diseases including type 2 diabetes. Therefore, we designed a study to evaluate pancreatic beta cells and mast cells during chlamydial infection. Our study revealed that C. pneumoniae infected mast cells significantly (p< 0.005) decreased beta cell ATP and insulin production, in contrast to uninfected mast cells co-cultured with beta cells. Infected mast cells exhibited pyknotic nuclei and active caspase-3 and caspase-1 expression. Additionally, ex vivo analyses of tissues collected from C. pneumoniae infected mice showed increased interleukin-1? production in splenocytes and pancreatic tissues as was observed with in vitro mast cell-beta cell co-cultures during C. pneumoniae infection. Notably, infected mast cells promoted beta cell destruction. Our findings reveal the negative effect of C. pneumoniae on mast cells, and the consequential impact on pancreatic beta cell function and viability. äChlamydia pneumoniae Promotes Dysfunction of Pancreatic Beta Cells (epmc).pdf DeepDyve Pubget Overpricing