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10.3892/ijmm.2015.2268 http://scihub22266oqcxt.onion/10.3892/ijmm.2015.2268 C4533784!4533784 !26133118     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 286.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26133118 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Med 2015 ; 36 (3 ): 645-52 Nephropedia Template TP {{tp|p=26133118 |t=2015. Bufalin inhibits TGF-?-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-? receptors |pdf=|usr=}}{{26133118 }} gab.com Text Bufalin inhibits TGF- -induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF- receptors JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26133118 #FOAvip The epithelial-to-mesenchymal transition (EMT) is a well-known prerequisite for cancer cells to acquire the migratory and invasive capacity, and to subsequently metastasize. Bufalin is one of the major active components of the traditional Chinese medicine Chan Su, and accumulating evidence has shown its anticancer effect in multipe types of cancer. However, the role of bufalin in transforming growth factor?? (TGF??)?induced EMT and migration remains unclear. In the present study, the effect of bufalin on TGF???induced EMT and migration was investigated in human lung cancer A549 cells. TGF?? induced EMT in A549 cells and increased their migratory ability, which were markedly suppressed by bufalin. Additionally, TGF???induced upregulation of Twist2 and zinc finger E?box binding homeobox 2 (ZEB2), as well as the phosphorylation of Smad2 and Smad3 were also inhibited by bufalin. However, the Smad?independent signaling pathways were not affected. Further analysis showed that the TGF?? receptor I (T?RI) and TGF?? receptor II (T?RII) were downregulated in the presence of bufalin. Pretreatment with SB431542, a potent inhibitor of the phosphorylation of T?RI, significantly attenuated TGF???induced EMT, mimicking the effect of bufalin on A549 cells. Taken together, these results suggest that bufalin suppresses TGF-?-induced EMT and migration by downregulating T?RI and T?RII in A549 cells. Twit Text FOAVip Bufalin inhibits TGF- -induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF- receptors ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26133118 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26133118 #FOAvip English Wikipedia <ref>{{Cite pmid|26133118 }}</ref> Bufalin inhibits TGF-?-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-? receptors #MMPMID26133118 Zhao L ; Liu S ; Che X ; Hou K ; Ma Y ; Li C ; Wen T ; Fan Y ; Hu X ; Liu Y ; Qu X Int J Mol Med 2015[Sep]; 36 (3 ): 645-52 PMID26133118 show ga The epithelial-to-mesenchymal transition (EMT) is a well-known prerequisite for cancer cells to acquire the migratory and invasive capacity, and to subsequently metastasize. Bufalin is one of the major active components of the traditional Chinese medicine Chan Su, and accumulating evidence has shown its anticancer effect in multipe types of cancer. However, the role of bufalin in transforming growth factor?? (TGF??)?induced EMT and migration remains unclear. In the present study, the effect of bufalin on TGF???induced EMT and migration was investigated in human lung cancer A549 cells. TGF?? induced EMT in A549 cells and increased their migratory ability, which were markedly suppressed by bufalin. Additionally, TGF???induced upregulation of Twist2 and zinc finger E?box binding homeobox 2 (ZEB2), as well as the phosphorylation of Smad2 and Smad3 were also inhibited by bufalin. However, the Smad?independent signaling pathways were not affected. Further analysis showed that the TGF?? receptor I (T?RI) and TGF?? receptor II (T?RII) were downregulated in the presence of bufalin. Pretreatment with SB431542, a potent inhibitor of the phosphorylation of T?RI, significantly attenuated TGF???induced EMT, mimicking the effect of bufalin on A549 cells. Taken together, these results suggest that bufalin suppresses TGF-?-induced EMT and migration by downregulating T?RI and T?RII in A549 cells. |Antineoplastic Agents/*pharmacology [MESH] |Bufanolides/*pharmacology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Down-Regulation/drug effects [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Humans [MESH] |Lung Neoplasms/*drug therapy/metabolism/pathology [MESH] |Lung/*drug effects/metabolism/pathology [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptor, Transforming Growth Factor-beta Type II [MESH] |Receptors, Transforming Growth Factor beta/metabolism [MESH]Bufalin inhibits TGF-?-induced epithelial-to-mesenchymal transition an(epmc).pdf DeepDyve Pubget Overpricing