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10.1111/micc.12192 http://scihub22266oqcxt.onion/10.1111/micc.12192 C4532430!4532430!25660131     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microcirculation 2015 ; 22 (4): 257-66 Nephropedia Template TP {{tp|p=25660131|t=2015. Obesity alters the peripheral circadian clock in the aorta and microcirculation |pdf=|usr=}}{{25660131}} gab.com Text Obesity alters the peripheral circadian clock in the aorta and microcirculation JO: Microcirculation http://www.kidney.de/pget.php?&tw=1&pmid=25660131 #FOAvip Perturbation of daily rhythm increases cardiovascular risk. The aim of this study was to determine whether obesity alters circadian gene expression and microvascular function in lean mice and obese (db/db) mice. Mice were subjected to normal light-dark cycle or constant darkness (DD) to alter circadian rhythm. Metabolic parameters and microvascular vasoreactivity were evaluated. Array studies were conducted in the AM and PM cycles to assess the rhythmicity of the entire genomics. Rhythmic expression of specific clock genes (Bmal1, Clock, Npas2, Per1, Per2, and Cry1), clock output genes (dbp), and vascular relaxation-related genes (eNOS, GTPCH1) were assessed. Obesity was associated with metabolic dysfunction and impaired endothelial dilation in the microvasculature. Circadian rhythm of gene expression was suppressed 80% in both macro- and microcirculations of obese mice. Circadian disruption with DD increased fasting serum glucose and HbA1C in obese but not lean mice. Endothelium-dependent dilation was attenuated in obese mice and in lean mice subjected to DD. Rhythmic expression of per1 and dbp was depressed in obesity. Expression of eNOS expression was suppressed and GTPCH1 lost rhythmic expression both in obesity and by constant darkness. These results suggest that obesity reduces circadian gene expression in concert with impaired endothelial function. The causal relationship remains to be determined. Twit Text FOAVip Obesity alters the peripheral circadian clock in the aorta and microcirculation ????Microcirculation http://www.kidney.de/pget.php?&tw=1&pmid=25660131 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25660131 #FOAvip English Wikipedia <ref>{{Cite pmid|25660131}}</ref> Obesity alters the peripheral circadian clock in the aorta and microcirculation #MMPMID25660131 Nernpermpisooth N; Qiu S; Mintz JD; Suvitayavat W; Thirawarapan S; Rudic DR; Fulton DJ; Stepp DW Microcirculation 2015[May]; 22 (4): 257-66 PMID25660131show ga Perturbation of daily rhythm increases cardiovascular risk. The aim of this study was to determine whether obesity alters circadian gene expression and microvascular function in lean mice and obese (db/db) mice. Mice were subjected to normal light-dark cycle or constant darkness (DD) to alter circadian rhythm. Metabolic parameters and microvascular vasoreactivity were evaluated. Array studies were conducted in the AM and PM cycles to assess the rhythmicity of the entire genomics. Rhythmic expression of specific clock genes (Bmal1, Clock, Npas2, Per1, Per2, and Cry1), clock output genes (dbp), and vascular relaxation-related genes (eNOS, GTPCH1) were assessed. Obesity was associated with metabolic dysfunction and impaired endothelial dilation in the microvasculature. Circadian rhythm of gene expression was suppressed 80% in both macro- and microcirculations of obese mice. Circadian disruption with DD increased fasting serum glucose and HbA1C in obese but not lean mice. Endothelium-dependent dilation was attenuated in obese mice and in lean mice subjected to DD. Rhythmic expression of per1 and dbp was depressed in obesity. Expression of eNOS expression was suppressed and GTPCH1 lost rhythmic expression both in obesity and by constant darkness. These results suggest that obesity reduces circadian gene expression in concert with impaired endothelial function. The causal relationship remains to be determined. äObesity alters the peripheral circadian clock in the aorta and microci(epmc).pdf DeepDyve Pubget Overpricing