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1988 ; 3
(1
): 72-6
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English Wikipedia
Clinical review of 20 cases of Addison s disease in Korea--including previously
reported cases and 6 new cases at the National Medical Center
#MMPMID3153796
Sung SK
; Kwon YJ
; Lee BW
; Kim DM
; Yoo HJ
Korean J Intern Med
1988[Jan]; 3
(1
): 72-6
PMID3153796
show ga
Addison?s disease is a rare disorder resulting from a chronic deficiency of
adrenol cortical hormone. The clinical manifestations and data of 20 patients
with Addison?s disease were reviewed. They include 14 previously reported cases,
total cases in korea upto 1987, and 6 new cases at National Medical Center. 1. 13
patients were male and 7 female. The mean age was 39 years and ranged from 16 to
61 years. 2. Common symptoms included mucocutaneous pigmentation (95 %), general
weakness (90%), nasuea and/or vomiting (80%), and weight loss (60%). 3. Initial
mean blood pressure was 96±21/63±14 mmHg and adrenal crises were found in 5 cases
(25%). 4. Laboratory data indicated hyponatremia and hyperkalemia, resulting in a
decreased Na/K ratio. Serum basal cortisol and ACTH levels were 2.86±1.93 ug/dl
and 482.5/269.3 pg/ml, respectively. 5. Extra-adrenal tuberculosis was present in
14 cases (70%) as a very high incidence. 6. These 14 cases (70%) were presumed to
be due to adrenal tuberculosis, although only two cases were confirmed as such by
histopathology. The other cases were likely to be non-tuberculous. Thus,
tuberculosis may be-considered as a predominant cause of Addision?s disease in
Korea. Other features were not unusual. But further detailed and extensive
studies are necessary including more pathologically confirmed cases.