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Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Korean+J+Intern+Med 1995 ; 10 (1): 68-72 Nephropedia Template TP
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Cushing?s Syndrome Due To Primary Pigmented Nodular Adrenocortical Disease: ?A Case Report Reviews of The Literature? #MMPMID7626560
Choi KM; Seu JH; Kim YH; Lee EJ; Kim SJ; Baik SH; Choi DS
Korean J Intern Med 1995[Jan]; 10 (1): 68-72 PMID7626560show ga
Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of Cushing?s syndrome in infants, children and young adults. It is characterized by non-adrenocorticotropic hormone-dependent hypersecretion of cortisol by multiple, pigmented nodules of hyperplastic adrenocortical cells. Biochemically, PPNAD is characterized by elevated levels of plasma and urinary cortisol that are not suppressed by high doses of dexamethasone (8mg/d for 2 days). Pathologically, the adrenal glands contain multiple dark brown or black nodules and the intervening cortical tissue is atrophic. Recognition of this diagnosis, although rare, is important, as bilateral adrenalectomy is the treatment of choice.We experienced a case of Cushing?s syndrome due to primary pigmented nodular adrenocortical disease and report it with reviews of the literature.