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10.3904/kjim.1995.10.1.68

http://scihub22266oqcxt.onion/10.3904/kjim.1995.10.1.68
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suck abstract from ncbi


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pmid7626560
      Korean+J+Intern+Med 1995 ; 10 (1 ): 68-72
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  • Cushing s syndrome due to primary pigmented nodular adrenocortical disease--a case report reviews of the literature #MMPMID7626560
  • Choi KM ; Seu JH ; Kim YH ; Lee EJ ; Kim SJ ; Baik SH ; Choi DS
  • Korean J Intern Med 1995[Jan]; 10 (1 ): 68-72 PMID7626560 show ga
  • Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of Cushing's syndrome in infants, children and young adults. It is characterized by non-adrenocorticotropic hormone-dependent hypersecretion of cortisol by multiple, pigmented nodules of hyperplastic adrenocortical cells. Biochemically, PPNAD is characterized by elevated levels of plasma and urinary cortisol that are not suppressed by high doses of dexamethasone (8mg/d for 2 days). Pathologically, the adrenal glands contain multiple dark brown or black nodules and the intervening cortical tissue is atrophic. Recognition of this diagnosis, although rare, is important, as bilateral adrenalectomy is the treatment of choice. We experienced a case of Cushing's syndrome due to primary pigmented nodular adrenocortical disease and report it with reviews of the literature.
  • |Adrenal Cortex Diseases/*complications/surgery [MESH]
  • |Adrenal Cortex/metabolism/pathology [MESH]
  • |Adrenalectomy [MESH]
  • |Adult [MESH]
  • |Cushing Syndrome/*etiology/surgery [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Hydrocortisone/metabolism [MESH]
  • |Hyperpigmentation/*complications/surgery [MESH]
  • |Hyperplasia [MESH]


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