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1996 ; 11
(2
): 122-32
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Nonspecific interstitial pneumonia/fibrosis: clinical manifestations, histologic
and radiologic features
#MMPMID8854648
Park CS
; Jeon JW
; Park SW
; Lim GI
; Jeong SH
; Uh ST
; Park JS
; Choi DL
; Jin SY
; Kang CH
Korean J Intern Med
1996[Jun]; 11
(2
): 122-32
PMID8854648
show ga
OBJECTIVES: Customarily used classification of IPF did not satisfy a sizable
group of patients with IPF that in the past had been lumped with UIP and now
currently has begun to be recognized as nonspecific interstitial
pneumonia/fibrosis (NIP). There are few reports about the clinical features of
NIP. METHODS: The pathologic slides of 66 patients having open lung biopsy (OLB)
for the differential diagnosis of interstitial lung diseases (ILD) from 1984 to
1995 were reviewed. Seven cases were confirmed as NIP. The clinical record,
pulmonary function tests (PFT), chest PA and HRCT were reviewed and analysed
retrospectively. RESULTS: Six patients with NIP were female. The median age was
56 years. Mean duration of symptoms was 4 months. Five patients had systemic
flu-like symptoms, the most common respiratory symptom was gradual dyspnea. Two
patients revealed a mild degree of anemia. Four cases had leukocytois of more
than 10,000/mm3. ESR and CRP O.K. elevated in all measured cases. Anti-nuclear
antibody (ANA) was positive in three of six patients and ds-DNA antibody was
positive in one of six patients. Restrictive pattern of PFT was predominant.
Diffusion capacity of carbon monoxide (DLCO) decreased markedly. In
bronchoalveolar lavage (BAL), total cell counts elevated about three times of
normal value. On differential counts of BAL cells, lymphocytes, neutrophils and
eosinophils were higher than those of normal controls. The prominent finding of
chest radiology was bilaterally patchy opacifications in parenchyme of lower lung
zones. On HRCT, bilaterally patchy areas of ground-glass attenuation and/or areas
of alveolar consolidation were commonly shown. The number of pathologic type was
one case of group I, four cases of group II and two cases of group III. The
average period from diagnosis to the last follow-up was 24.8 months. Five
patients were clinically recovered to the previously well-being state.
CONCLUSION: Patients with NIP had different clinical features from UIP, AIP and
DIP. They also had characteristic findings of radiology and their prognosis seems
to be better than UIP.
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