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10.3904/kjim.1997.12.2.176 http://scihub22266oqcxt.onion/10.3904/kjim.1997.12.2.176 C4531986!4531986 !9439152     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=9439152 &cmd=llinks): Failed to open stream: HTTP request failed! 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Clinical significances of antibodies to Ro/SS-A autoantigens and its subtypes in primary Sjögren s syndrome |pdf=|usr=}}{{9439152 }} gab.com Text Clinical significances of antibodies to Ro/SS-A autoantigens and its subtypes in primary Sjögren s syndrome JO: Korean J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=9439152 #FOAvip OBJECTIVE: To evaluate the patterns of Ro autoantigen recognition in Korean patients with primary Sjögren's syndrome (SS) and to investigate its clinical significance in SS. METHODS: Sera from primary SS (n = 51) and systemic lupus erythematosus (SLE) (n = 132) were tested by double immunodiffusion test and immunoblotting for reactivity with 60 kDa and 52 kDa Ro/SS-A proteins. Clinical manifestations were evaluated on the basis of the presence of anti-Ro/SS-A antibodies and anti-60 kDa/52 kDa proteins. RESULTS: The prevalence of anti-Ro/SS-A antibodies in Korean patients with primary SS was 64.7%. In immunoblotting analysis, the incidence of anti-60 kDa without anti-52 kDa was lower in patients with SS(3.0% vs. 11.6%, p > 0.05), whereas anti-52 kDa without anti-60 kDa was more common in SS patients than in SLE patients(42.5% vs. 4.3%, p < 0.001). Patients with anti-Ro/SS-A antibody were significantly associated with the presence of vasculitis, hyperglobulinemia and rheumatoid factor in primary SS (p < 0.05). CONCLUSION: The patterns of 52 kDa and 60 kDa Ro autoantigen recognition were quite different in the SLE and primary SS. Anti-52 kDa without anti-60 kDa antibody may be used as a diagnostic marker for primary SS. Although the presence of anti-Ro/SS-A antibody was closely associated with certain clinical features in SS, these clinical manifestations were not correlated with the presence of antibodies against each 52 kDa and 60 kDa proteins. Extended studies with a large population are required to determine the clinical correlation of autoantibodies against each peptides or epitopes of Ro/SS-A proteins. Twit Text FOAVip Clinical significances of antibodies to Ro/SS-A autoantigens and its subtypes in primary Sjögren s syndrome ????Korean J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=9439152 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=9439152 #FOAvip English Wikipedia <ref>{{Cite pmid|9439152 }}</ref> Clinical significances of antibodies to Ro/SS-A autoantigens and its subtypes in primary Sjögren s syndrome #MMPMID9439152 Cho CS ; Park SH ; Min JK ; Lee SH ; Kim HY Korean J Intern Med 1997[Jun]; 12 (2 ): 176-81 PMID9439152 show ga OBJECTIVE: To evaluate the patterns of Ro autoantigen recognition in Korean patients with primary Sjögren's syndrome (SS) and to investigate its clinical significance in SS. METHODS: Sera from primary SS (n = 51) and systemic lupus erythematosus (SLE) (n = 132) were tested by double immunodiffusion test and immunoblotting for reactivity with 60 kDa and 52 kDa Ro/SS-A proteins. Clinical manifestations were evaluated on the basis of the presence of anti-Ro/SS-A antibodies and anti-60 kDa/52 kDa proteins. RESULTS: The prevalence of anti-Ro/SS-A antibodies in Korean patients with primary SS was 64.7%. In immunoblotting analysis, the incidence of anti-60 kDa without anti-52 kDa was lower in patients with SS(3.0% vs. 11.6%, p > 0.05), whereas anti-52 kDa without anti-60 kDa was more common in SS patients than in SLE patients(42.5% vs. 4.3%, p < 0.001). Patients with anti-Ro/SS-A antibody were significantly associated with the presence of vasculitis, hyperglobulinemia and rheumatoid factor in primary SS (p < 0.05). CONCLUSION: The patterns of 52 kDa and 60 kDa Ro autoantigen recognition were quite different in the SLE and primary SS. Anti-52 kDa without anti-60 kDa antibody may be used as a diagnostic marker for primary SS. Although the presence of anti-Ro/SS-A antibody was closely associated with certain clinical features in SS, these clinical manifestations were not correlated with the presence of antibodies against each 52 kDa and 60 kDa proteins. Extended studies with a large population are required to determine the clinical correlation of autoantibodies against each peptides or epitopes of Ro/SS-A proteins. |*RNA, Small Cytoplasmic [MESH] |Adult [MESH] |Aged [MESH] |Antibodies, Antinuclear/*analysis [MESH] |Autoantigens/*immunology [MESH] |Humans [MESH] |Lupus Erythematosus, Systemic/immunology [MESH] |Middle Aged [MESH] |Molecular Weight [MESH] |Ribonucleoproteins/*immunology [MESH]Clinical significances of antibodies to Ro/SS-A autoantigens and its s(epmc).pdf DeepDyve Pubget Overpricing