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10.3904/kjim.1997.12.1.67 http://scihub22266oqcxt.onion/10.3904/kjim.1997.12.1.67 C4531964!4531964 !9159041     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=9159041 &cmd=llinks): Failed to open stream: HTTP request failed! 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The effect of diphenyl-dimethyl-dicarboxylate on cyclosporine-A blood level in kidney transplants with chronic hepatitis |pdf=|usr=}}{{9159041 }} gab.com Text The effect of diphenyl-dimethyl-dicarboxylate on cyclosporine-A blood level in kidney transplants with chronic hepatitis JO: Korean J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=9159041 #FOAvip An adequate blood level of cyclosporine-A (CsA) is essential to keep graft function in kidney transplants. Due to a narrow therapeutic index and highly variable pharmacokinetic properties associated with CsA, drug interactions may have a significant impact on the immunosuppressive efficacy or toxicity of CsA. Numerous drug interactions of potential clinical significance involving CsA have been reported. Dephenyl-dimethyl-dicarboxylate (PMC), a hepatotonic drug, is a substance derived from the synthesis of Schizandrae fructus elements. We have experienced two cases of drug interaction between CsA and PMC in kidney transplants with chronic hepatitis. In both cases, CsA troughs decreased markedly to a subtherapeutic level following administration of PMC. We, therefore, suggest that PMC could decrease the CsA trough level and thus a close monitoring of the CsA trough level is necessary during a PMC therapy. Twit Text FOAVip The effect of diphenyl-dimethyl-dicarboxylate on cyclosporine-A blood level in kidney transplants with chronic hepatitis ????Korean J Intern Med http://www.kidney.de/pget.php?&tw=1&pmid=9159041 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=9159041 #FOAvip English Wikipedia <ref>{{Cite pmid|9159041 }}</ref> The effect of diphenyl-dimethyl-dicarboxylate on cyclosporine-A blood level in kidney transplants with chronic hepatitis #MMPMID9159041 Kim YS ; Kim DH ; Kim DO ; Lee BK ; Kim KW ; Park JN ; Lee JC ; Choi YS ; Rim H Korean J Intern Med 1997[Jan]; 12 (1 ): 67-9 PMID9159041 show ga An adequate blood level of cyclosporine-A (CsA) is essential to keep graft function in kidney transplants. Due to a narrow therapeutic index and highly variable pharmacokinetic properties associated with CsA, drug interactions may have a significant impact on the immunosuppressive efficacy or toxicity of CsA. Numerous drug interactions of potential clinical significance involving CsA have been reported. Dephenyl-dimethyl-dicarboxylate (PMC), a hepatotonic drug, is a substance derived from the synthesis of Schizandrae fructus elements. We have experienced two cases of drug interaction between CsA and PMC in kidney transplants with chronic hepatitis. In both cases, CsA troughs decreased markedly to a subtherapeutic level following administration of PMC. We, therefore, suggest that PMC could decrease the CsA trough level and thus a close monitoring of the CsA trough level is necessary during a PMC therapy. |Chronic Disease [MESH] |Cyclosporine/*blood/therapeutic use [MESH] |Dioxoles/*pharmacology [MESH] |Drug Interactions [MESH] |Drugs, Chinese Herbal/*pharmacology [MESH] |Female [MESH] |Graft Rejection/drug therapy/physiopathology [MESH] |Hepatitis/physiopathology [MESH] |Humans [MESH] |Immunosuppressive Agents/*blood/therapeutic use [MESH] |Kidney Transplantation/*immunology [MESH] |Male [MESH] |Middle Aged [MESH]The effect of diphenyl-dimethyl-dicarboxylate on cyclosporine-A blood (epmc).pdf DeepDyve Pubget Overpricing