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10.3904/kjim.2001.16.3.160

http://scihub22266oqcxt.onion/10.3904/kjim.2001.16.3.160
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C4531722!4531722!11769574
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suck abstract from ncbi


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pmid11769574      Korean+J+Intern+Med 2001 ; 16 (3): 160-6
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  • Ultrastructural Changes of Hepatic Stellate Cells in the Space of Disse in Alcoholic Fatty Liver #MMPMID11769574
  • Han NI; Chung KW; Ahn BM; Choi SW; Lee YS; Lee CD; Sun HS
  • Korean J Intern Med 2001[Sep]; 16 (3): 160-6 PMID11769574show ga
  • Background :: Hepatic stellate cell (HSC) has been suggested to play a role in fibrogenesis in alcoholic liver disease. We evaluate the correlation with fibrogenesis and ultrastructure of hepatic stellate cells in alcoholic fatty liver. Methods :: We studied 6 patients with alcoholic fatty liver and 5 non-alcoholic fatty liver. The numbers of fat droplets in hepatic stellate cell was determined by electron microscopy. We also studied the grading of deposition of collagen fibers in the space of Disse. We were to evaluate the structure of hepatic stellate cells in the space of Disse by light and electron microscopy. Results :: Wider distribution of fat droplets in hepatic stellate cells in alcoholic fatty liver than in normal liver. The hypertrophied endoplasmic reticulum in hepatic stellate cells is a prominent findings in alcoholic fatty liver. We observed basement membrane-like materials in patients with alcoholic fatty liver with hepatic fibrosis. Conclusion :: The results demonstrate that, in patients with alcoholic fatty liver by alcoholic liver injury, the hepatic stellate cells may play an important role in the fibrogenesis of perisinusoidal spaces in the liver.
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