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2015 ; 34
(3
): 1106-14
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Natural and adaptive IgM antibodies in the recognition of tumor-associated
antigens of breast cancer (Review)
#MMPMID26133558
Díaz-Zaragoza M
; Hernández-Ávila R
; Viedma-Rodríguez R
; Arenas-Aranda D
; Ostoa-Saloma P
Oncol Rep
2015[Sep]; 34
(3
): 1106-14
PMID26133558
show ga
For early detection of cancer, education and screening are important, but the
most critical factor is the development of early diagnostic tools. Methods that
recognize the warning signs of cancer and take prompt action lead to an early
diagnosis; simple tests can identify individuals in a healthy population who have
the disease but have not developed symptoms. Early detection of cancer is
significant and is one of the most promising approaches by which to reduce the
growing cancer burden and guide curative treatment. The early diagnosis of
patients with breast cancer is challenging, since it is the most common cancer in
women worldwide. Despite the advent of mammography in screening for breast
cancer, low-resource, low-cost alternative tools must be implemented to
complement mammography findings. IgM is part of the first line of defense of an
organism and is responsible for recognizing and eliminating infectious particles
and removing transformed cells. Most studies on breast cancer have focused on the
development of IgG-like molecules as biomarkers or as a treatment for the
advanced stages of cancer, but autoantibodies (IgM) and tumor-associated antigens
(proteins or carbohydrates with aberrant structures) have not been examined as
early diagnostic tools for breast cancer. The present review summarizes the
function of natural and adaptive IgM in eliminating cancer cells in the early
stages of pathology and their value as early diagnostic tools. IgM, as a
component of the immune system, is being used to identify tumor-associated
antigens and tumor-associated carbohydrate antigens.
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