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2015 ; 8
(5
): 278-84
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The role of AST-120 and protein-bound uremic toxins in irritable bowel syndrome:
a therapeutic perspective
#MMPMID26327918
Mosi?ska P
; Storr M
; Fichna J
Therap Adv Gastroenterol
2015[Sep]; 8
(5
): 278-84
PMID26327918
show ga
AST-120 (kremezin) exhibits its favourable effects in reducing the levels of
renal toxins by selective adsorption of low molecular weight substances from the
intestinal lumen. So far, a vast majority of studies were focused on the role of
AST-120 in the treatment of chronic kidney diseases and cardiovascular disorders,
and positive therapeutic effects of the agent have already been confirmed in
clinical conditions. Up to the present, there are only a few studies regarding
the role of AST-120 in irritable bowel syndrome (IBS). Compelling data suggest
the ability of the compound to adsorb protein-bound uremic toxins and mast cell
derived mediators and to modulate the farnesoid X receptor, which is a bile acid
sensor indispensable for maintaining homeostasis in the intestine. In this review
we focus on the actions of AST-120 on intestinal permeability, reduction of
visceral sensitivity and alteration of gut motility. We also discuss whether
AST-120 can mitigate common IBS symptoms, such as abdominal pain, bloating and
malfunction of the colonic transit and thus improve the quality of life of
patients with IBS.