Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25864519
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Transpl+Int
2015 ; 28
(9
): 1121-5
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cytomegalovirus-induced thrombotic microangiopathy after renal transplant
successfully treated with eculizumab: case report and review of the literature
#MMPMID25864519
Java A
; Edwards A
; Rossi A
; Pandey R
; Gaut J
; Delos Santos R
; Miller B
; Klein C
; Brennan D
Transpl Int
2015[Sep]; 28
(9
): 1121-5
PMID25864519
show ga
De novo thrombotic microangiopathy (TMA) after renal transplant is rare.
Cytomegalovirus (CMV)-related post-transplant TMA has only been reported in 6
cases. We report an unusual case of a 75-year-old woman who developed de novo TMA
in association with CMV viremia. The recurrence of TMA with CMV viremia, the
resolution with treatment for CMV, and the lack of correlation with a calcineurin
inhibitor (CNI) in our case support CMV as the cause of the TMA. What is unique
is that the use of eculizumab without plasmapheresis led to prompt improvement in
renal function. After a failure to identify a genetic cause for TMA and the clear
association with CMV, eculizumab was discontinued. This case provides insight
into the pathogenesis and novel treatment of de novo TMA, highlights the
beneficial effects of complement inhibitors in this disease, and shows that they
can be safely discontinued once the inciting etiology is addressed.
|Aged
[MESH]
|Antibodies, Monoclonal, Humanized/*therapeutic use
[MESH]