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10.2147/DDDT.S86370 http://scihub22266oqcxt.onion/10.2147/DDDT.S86370 C4529266!4529266 !26345516     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26345516 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Drug+Des+Devel+Ther 2015 ; 9 (ä): 4209-18 Nephropedia Template TP {{tp|p=26345516 |t=2015. Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin |pdf=|usr=}}{{26345516 }} gab.com Text Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin JO: Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=26345516 #FOAvip Phytantriol- and glycerol monooleate-based cubosomes were produced and characterized as a targeted and sustained transdermal delivery system for capsaicin. The cubosomes were prepared by emulsification and homogenization of phytantriol (F1), glycerol monooleate (F2), and poloxamer dispersions, characterized for morphology and particle size distribution by transmission electron microscope and photon correlation spectroscopy. Their Im3m crystallographic space group was confirmed by small-angle X-ray scattering. An in vitro release study showed that the cubosomes provided a sustained release system for capsaicin. An in vitro diffusion study conducted using Franz diffusion cells indicated that the skin retention of capsaicin from cubosomes in the stratum corneum was much higher (2.75±0.22 ?g versus 4.32±0.13 ?g, respectively) than that of capsaicin cream (0.72±0.13 ?g). The stress testing showed that the cubosome formulations were stable under strong light and high temperature for up to 10 days. After multiapplications on mouse skin, the irritation of capsaicin cubosomes and cream was light with the least amount of side effects. Overall, the present study demonstrated that cubosomes may be a suitable skin-targeted and sustained delivery system for the transdermal administration of capsaicin. Twit Text FOAVip Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin ????Drug Des Devel Ther http://www.kidney.de/pget.php?&tw=1&pmid=26345516 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26345516 #FOAvip English Wikipedia <ref>{{Cite pmid|26345516 }}</ref> Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin #MMPMID26345516 Peng X ; Zhou Y ; Han K ; Qin L ; Dian L ; Li G ; Pan X ; Wu C Drug Des Devel Ther 2015[]; 9 (ä): 4209-18 PMID26345516 show ga Phytantriol- and glycerol monooleate-based cubosomes were produced and characterized as a targeted and sustained transdermal delivery system for capsaicin. The cubosomes were prepared by emulsification and homogenization of phytantriol (F1), glycerol monooleate (F2), and poloxamer dispersions, characterized for morphology and particle size distribution by transmission electron microscope and photon correlation spectroscopy. Their Im3m crystallographic space group was confirmed by small-angle X-ray scattering. An in vitro release study showed that the cubosomes provided a sustained release system for capsaicin. An in vitro diffusion study conducted using Franz diffusion cells indicated that the skin retention of capsaicin from cubosomes in the stratum corneum was much higher (2.75±0.22 ?g versus 4.32±0.13 ?g, respectively) than that of capsaicin cream (0.72±0.13 ?g). The stress testing showed that the cubosome formulations were stable under strong light and high temperature for up to 10 days. After multiapplications on mouse skin, the irritation of capsaicin cubosomes and cream was light with the least amount of side effects. Overall, the present study demonstrated that cubosomes may be a suitable skin-targeted and sustained delivery system for the transdermal administration of capsaicin. |*Drug Carriers [MESH] |Administration, Cutaneous [MESH] |Animals [MESH] |Capsaicin/*administration & dosage/chemistry/metabolism [MESH] |Chemistry, Pharmaceutical [MESH] |Crystallography, X-Ray [MESH] |Delayed-Action Preparations [MESH] |Diffusion [MESH] |Drug Stability [MESH] |Emulsions [MESH] |Fatty Alcohols/*chemistry/toxicity [MESH] |Glycerides/*chemistry/toxicity [MESH] |Kinetics [MESH] |Mice [MESH] |Microscopy, Electron, Transmission [MESH] |Ointments [MESH] |Particle Size [MESH] |Poloxamer/*chemistry/toxicity [MESH] |Rats, Sprague-Dawley [MESH] |Scattering, Small Angle [MESH] |Skin Absorption [MESH] |Skin/metabolism [MESH] |Solubility [MESH]Characterization of cubosomes as a targeted and sustained transdermal (epmc).pdf DeepDyve Pubget Overpricing