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10.2217/pgs.15.42 http://scihub22266oqcxt.onion/10.2217/pgs.15.42 C4527535!4527535!26067485     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacogenomics 2015 ; 16 (8): 841-54 Nephropedia Template TP {{tp|p=26067485|t=2015. Multigene predictors of tacrolimus exposure in kidney transplant recipients |pdf=|usr=}}{{26067485}} gab.com Text Multigene predictors of tacrolimus exposure in kidney transplant recipients JO: Pharmacogenomics http://www.kidney.de/pget.php?&tw=1&pmid=26067485 #FOAvip Aim:: Determine the effect of the genetic variants beyond CYP3A5*3 on tacrolimus disposition. Patients & methods:: We studied genetic correlates of tacrolimus trough concentrations with POR*28, CYP3A4*22 and ABCC2 haplotypes in a large, ethnically diverse kidney transplant cohort (n = 2008). Results:: Subjects carrying one or more CYP3A5*1 alleles had lower tacrolimus trough concentrations (p = 9.2 × 10-75). The presence of one or two POR*28 alleles was associated with a 4.63% reduction in tacrolimus trough concentrations after adjusting for CYP3A5*1 and clinical factors (p = 0.037). In subset analyses, POR*28 was significant only in CYP3A5*3/*3 carriers (p = 0.03). The CYP3A4*22 variant and the ABBC2 haplotypes were not associated. Conclusion:: This study confirmed that CYP3A5*1 was associated with lower tacrolimus trough concentrations. POR*28 was associated with decreased tacrolimus trough concentrations although the effect was small possibly through enhanced CYP3A4 enzyme activity. CYP3A4*22 and ABCC2 haplotypes did not influence tacrolimus trough concentrations. Twit Text FOAVip Multigene predictors of tacrolimus exposure in kidney transplant recipients ????Pharmacogenomics http://www.kidney.de/pget.php?&tw=1&pmid=26067485 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26067485 #FOAvip English Wikipedia <ref>{{Cite pmid|26067485}}</ref> Multigene predictors of tacrolimus exposure in kidney transplant recipients #MMPMID26067485 Pulk RA; Schladt DS; Oetting WS; Guan W; Israni AK; Matas AJ; Remmel RP; Jacobson PA Pharmacogenomics 2015[Jun]; 16 (8): 841-54 PMID26067485show ga Aim:: Determine the effect of the genetic variants beyond CYP3A5*3 on tacrolimus disposition. Patients & methods:: We studied genetic correlates of tacrolimus trough concentrations with POR*28, CYP3A4*22 and ABCC2 haplotypes in a large, ethnically diverse kidney transplant cohort (n = 2008). Results:: Subjects carrying one or more CYP3A5*1 alleles had lower tacrolimus trough concentrations (p = 9.2 × 10-75). The presence of one or two POR*28 alleles was associated with a 4.63% reduction in tacrolimus trough concentrations after adjusting for CYP3A5*1 and clinical factors (p = 0.037). In subset analyses, POR*28 was significant only in CYP3A5*3/*3 carriers (p = 0.03). The CYP3A4*22 variant and the ABBC2 haplotypes were not associated. Conclusion:: This study confirmed that CYP3A5*1 was associated with lower tacrolimus trough concentrations. POR*28 was associated with decreased tacrolimus trough concentrations although the effect was small possibly through enhanced CYP3A4 enzyme activity. CYP3A4*22 and ABCC2 haplotypes did not influence tacrolimus trough concentrations. äMultigene predictors of tacrolimus exposure in kidney transplant recip(epmc).pdf DeepDyve Pubget Overpricing