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10.3978/j.issn.2304-3881.2015.01.12 http://scihub22266oqcxt.onion/10.3978/j.issn.2304-3881.2015.01.12 C4526761!4526761!26312242     free     free     free       Hepatobiliary+Surg+Nutr 2015 ; 4 (4): 229-42 Nephropedia Template TP {{tp|p=26312242|t=2015. STRA6: role in cellular retinol uptake and efflux |pdf=|usr=}}{{26312242}} gab.com Text STRA6: role in cellular retinol uptake and efflux JO: Hepatobiliary Surg Nutr http://www.kidney.de/pget.php?&tw=1&pmid=26312242 #FOAvip Distribution of vitamin A throughout the body is important to maintain retinoid function in peripheral tissues and to ensure optimal vision. A critical step of this process is the transport of vitamin A across cell membranes. Increasing evidence indicates that this process is mediated by a multidomian membrane protein that is encoded by the stimulated by retinoic acid 6 (STRA6) gene. Biochemical studies revealed that STRA6 is a transmembrane pore which transports vitamin A bidirectionally between extra- and intracellular retinoid binding proteins. Vitamin A accumulation in cells is driven by coupling of transport with vitamin A esterification. Loss-of-function studies in zebrafish and mouse models have unraveled the critical importance of STRA6 for vitamin A homeostasis of peripheral tissues. Impairment in vitamin A transport and uptake homeostasis are associated with diseases including type 2 diabetes and a microphthalmic syndrome known as Matthew Wood Syndrome. This review will discuss the advanced state of knowledge about STRA6?s biochemistry, biology and association with disease. Twit Text FOAVip STRA6: role in cellular retinol uptake and efflux ????Hepatobiliary Surg Nutr http://www.kidney.de/pget.php?&tw=1&pmid=26312242 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26312242 #FOAvip English Wikipedia <ref>{{Cite pmid|26312242}}</ref> STRA6: role in cellular retinol uptake and efflux #MMPMID26312242 Kelly M; von Lintig J Hepatobiliary Surg Nutr 2015[Aug]; 4 (4): 229-42 PMID26312242show ga Distribution of vitamin A throughout the body is important to maintain retinoid function in peripheral tissues and to ensure optimal vision. A critical step of this process is the transport of vitamin A across cell membranes. Increasing evidence indicates that this process is mediated by a multidomian membrane protein that is encoded by the stimulated by retinoic acid 6 (STRA6) gene. Biochemical studies revealed that STRA6 is a transmembrane pore which transports vitamin A bidirectionally between extra- and intracellular retinoid binding proteins. Vitamin A accumulation in cells is driven by coupling of transport with vitamin A esterification. Loss-of-function studies in zebrafish and mouse models have unraveled the critical importance of STRA6 for vitamin A homeostasis of peripheral tissues. Impairment in vitamin A transport and uptake homeostasis are associated with diseases including type 2 diabetes and a microphthalmic syndrome known as Matthew Wood Syndrome. This review will discuss the advanced state of knowledge about STRA6?s biochemistry, biology and association with disease. äSTRA6: role in cellular retinol uptake and efflux (epmc).pdf DeepDyve Pubget Overpricing