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http://scihub22266oqcxt.onion/ C4525853!4525853 !26261519     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26261519 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Clin+Exp+Pathol 2015 ; 8 (6 ): 6434-41 Nephropedia Template TP {{tp|p=26261519 |t=2015. Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5 |pdf=|usr=}}{{26261519 }} gab.com Text Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5 JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26261519 #FOAvip Chemoresistance is a major obstacle to successful chemotherapy for glioma. Formononetin is a novel herbal isoflavonoid isolated from Astragalus membranaceus and possesses antitumorigenic properties. In the present study, we investigated the anti-proliferative effects of formononetin on human glioma cells, and further elucidated the molecular mechanism underlying the anti-tumor property. We found that formononetin enhanced doxorubicin cytotoxicity in glioma cells. Combined treatment with formononetin reversed the doxorubicin-induced epithelial-mesenchymal transition (EMT) in tumor cells. Moreover, we found that formononetin treatment significantly decreased the expression of HDAC5. Overexpression of HDAC5 diminished the suppressive effects of formononetin on glioma cell viability. Furthermore, knockdown of HDAC5 by siRNA inhibited the doxorubicin-induced EMT in glioma cells. Taken together, these results demonstrated that formononetin-combined therapy may enhance the therapeutic efficacy of doxorubicin in glioma cells by preventing EMT through inhibition of HDAC5. Twit Text FOAVip Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5 ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26261519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26261519 #FOAvip English Wikipedia <ref>{{Cite pmid|26261519 }}</ref> Formononetin sensitizes glioma cells to doxorubicin through preventing EMT via inhibition of histone deacetylase 5 #MMPMID26261519 Liu Q ; Sun Y ; Zheng JM ; Yan XL ; Chen HM ; Chen JK ; Huang HQ Int J Clin Exp Pathol 2015[]; 8 (6 ): 6434-41 PMID26261519 show ga Chemoresistance is a major obstacle to successful chemotherapy for glioma. Formononetin is a novel herbal isoflavonoid isolated from Astragalus membranaceus and possesses antitumorigenic properties. In the present study, we investigated the anti-proliferative effects of formononetin on human glioma cells, and further elucidated the molecular mechanism underlying the anti-tumor property. We found that formononetin enhanced doxorubicin cytotoxicity in glioma cells. Combined treatment with formononetin reversed the doxorubicin-induced epithelial-mesenchymal transition (EMT) in tumor cells. Moreover, we found that formononetin treatment significantly decreased the expression of HDAC5. Overexpression of HDAC5 diminished the suppressive effects of formononetin on glioma cell viability. Furthermore, knockdown of HDAC5 by siRNA inhibited the doxorubicin-induced EMT in glioma cells. Taken together, these results demonstrated that formononetin-combined therapy may enhance the therapeutic efficacy of doxorubicin in glioma cells by preventing EMT through inhibition of HDAC5. |Antibiotics, Antineoplastic/*pharmacology [MESH] |Antineoplastic Combined Chemotherapy Protocols/*pharmacology [MESH] |Brain Neoplasms/*drug therapy/enzymology/genetics/pathology [MESH] |Cell Line, Tumor [MESH] |Dose-Response Relationship, Drug [MESH] |Doxorubicin/*pharmacology [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Gene Expression Regulation, Enzymologic [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Glioma/*drug therapy/enzymology/genetics/pathology [MESH] |Histone Deacetylase Inhibitors/*pharmacology [MESH] |Histone Deacetylases/genetics/*metabolism [MESH] |Humans [MESH] |Isoflavones/*pharmacology [MESH] |RNA Interference [MESH] |Signal Transduction/drug effects [MESH]Formononetin sensitizes glioma cells to doxorubicin through preventing(epmc).pdf DeepDyve Pubget Overpricing