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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

http://scihub22266oqcxt.onion/ C4525813!4525813 !26261479     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26261479 &cmd=llinks): Failed to open stream: HTTP request failed! 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Protective effect of curcumin against experimentally induced aflatoxicosis on the renal cortex of adult male albino rats: a histological and immunohisochemical study |pdf=|usr=}}{{26261479 }} gab.com Text Protective effect of curcumin against experimentally induced aflatoxicosis on the renal cortex of adult male albino rats: a histological and immunohisochemical study JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26261479 #FOAvip BACKGROUND: Aflatoxin contamination of foods is a worldwide problem. Chronic aflatoxin exposure is associated with kidney damage. Curcumin is a herbal agent, used in medicine with a wide range of beneficial therapeutic effects. OBJECTIVE: to evaluate the effect of curcumin against experimentally induced aflatoxicosis on the renal cortex of adult male albino rats. MATERIALS AND METHODS: Forty adult male rats were included and they were divided equally into 4 groups (10 rats each): Group I (control group), group II (Curcumin group): The rats received curcumin (200 mg/kg b.w.) orally by gastric tube for 5 days/week, group III (Aflatoxin B1 group): The rats received aflatoxin B1 (250 ?g/kg b.w./day) orally by gastric tube 5 days/week for 4 weeks, group IV (Aflatoxin B1 and Curcumin group): The rats received aflatoxin and curcumin orally by gastric tube 5 days/week for 4 weeks. Kidney specimens were prepared and sections were stained with hematoxylin and eosin, Masson's trichrome, Periodic acid Schiff, immunohistochemical detection of desmin and Bcl2. RESULTS: The tubules of group III showed degenerative and necrotic changes with disruption of basal lamina. There was a significant decrease Bcl2 expression in the tubules, but the glomeruli showed an enlargement with dilation of their capillaries lumina in some areas, while the other areas showed glomerular atrophy with obliteration of their capillaries lumina. There was a significant increase in desmin expression in the glomerular cells. The interstitium showed hemorrhage and cellular infiltration. Group IV showed improvement of the histological and immunohistochemical changes described before. CONCLUSION: Aflatoxin B1 has deleterious effects of on the histological structure of the rat's renal cortex and curcumin minimized these effects as it has antioxidant, anti-inflammatory and antiapoptotic activities. We advise eating nutritious diets that contain sufficient amounts of curcumin and regulation must implement to avoid the presence of aflatoxins in high concentrations in human food. Twit Text FOAVip Protective effect of curcumin against experimentally induced aflatoxicosis on the renal cortex of adult male albino rats: a histological and immunohisochemical study ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26261479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26261479 #FOAvip English Wikipedia <ref>{{Cite pmid|26261479 }}</ref> Protective effect of curcumin against experimentally induced aflatoxicosis on the renal cortex of adult male albino rats: a histological and immunohisochemical study #MMPMID26261479 El-Mahalaway AM Int J Clin Exp Pathol 2015[]; 8 (6 ): 6019-30 PMID26261479 show ga BACKGROUND: Aflatoxin contamination of foods is a worldwide problem. Chronic aflatoxin exposure is associated with kidney damage. Curcumin is a herbal agent, used in medicine with a wide range of beneficial therapeutic effects. OBJECTIVE: to evaluate the effect of curcumin against experimentally induced aflatoxicosis on the renal cortex of adult male albino rats. MATERIALS AND METHODS: Forty adult male rats were included and they were divided equally into 4 groups (10 rats each): Group I (control group), group II (Curcumin group): The rats received curcumin (200 mg/kg b.w.) orally by gastric tube for 5 days/week, group III (Aflatoxin B1 group): The rats received aflatoxin B1 (250 ?g/kg b.w./day) orally by gastric tube 5 days/week for 4 weeks, group IV (Aflatoxin B1 and Curcumin group): The rats received aflatoxin and curcumin orally by gastric tube 5 days/week for 4 weeks. Kidney specimens were prepared and sections were stained with hematoxylin and eosin, Masson's trichrome, Periodic acid Schiff, immunohistochemical detection of desmin and Bcl2. RESULTS: The tubules of group III showed degenerative and necrotic changes with disruption of basal lamina. There was a significant decrease Bcl2 expression in the tubules, but the glomeruli showed an enlargement with dilation of their capillaries lumina in some areas, while the other areas showed glomerular atrophy with obliteration of their capillaries lumina. There was a significant increase in desmin expression in the glomerular cells. The interstitium showed hemorrhage and cellular infiltration. Group IV showed improvement of the histological and immunohistochemical changes described before. CONCLUSION: Aflatoxin B1 has deleterious effects of on the histological structure of the rat's renal cortex and curcumin minimized these effects as it has antioxidant, anti-inflammatory and antiapoptotic activities. We advise eating nutritious diets that contain sufficient amounts of curcumin and regulation must implement to avoid the presence of aflatoxins in high concentrations in human food. |*Aflatoxin B1 [MESH] |*Immunohistochemistry [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Curcumin/*pharmacology [MESH] |Cytoprotection [MESH] |Desmin/metabolism [MESH] |Disease Models, Animal [MESH] |Kidney Cortex/*drug effects/metabolism/pathology [MESH] |Kidney Diseases/chemically induced/metabolism/pathology/*prevention & control [MESH] |Male [MESH] |Mycotoxicosis/etiology/metabolism/pathology/*prevention & control [MESH] |Necrosis [MESH] |Protective Agents/*pharmacology [MESH] |Proto-Oncogene Proteins c-bcl-2/metabolism [MESH]Protective effect of curcumin against experimentally induced aflatoxic(epmc).pdf DeepDyve Pubget Overpricing